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ImmunoGen Announces Encouraging New Clinical Data With The Company's IMGN901 Compound In The Treatment Of Small-Cell Lung Cancer
ImmunoGen, Inc. (Nasdaq: IMGN), a biopharmaceutical company that develops targeted anticancer therapeutics using its Targeted Antibody Payload (TAP) technology, today announced the presentation of encouraging initial efficacy, safety and tolerability clinical data with its IMGN901 product candidate in the treatment of small-cell lung cancer (SCLC). In two early-stage clinical trials that enrolled patients whose SCLC had recurred following treatment with standard chemotherapies, IMGN901 administration achieved notable tumor shrinkage and/or sustained stable disease. The compound also demonstrated encouraging activity against other CD56-expressing (CD56+) solid tumors. These clinical data are being presented at the 13th World Conference on Lung Cancer taking place in San Francisco, CA, from July 31 to Aug. 4, 2009.
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The New Sports Supplement: Cereal And Milk
Exercise physiologist Lynne Kammer, from The University of Texas at Austin, led a group of researchers who investigated the post-exercise physiological effects of the foods. Kammer and her team studied 12 trained cyclists, 8 male and 4 female. In contrast to many sports nutrition studies, however, the exercise protocol was designed to reflect a typical exercise session. After a warm-up period, the subjects cycled for two hours at a comfortable work rate, rather than the more frequently seen test-to-exhaustion.
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Supreme Court Nominee Sotomayor Would Be Sixth Catholic On Bench
If Judge Sonia Sotomayor is confirmed to replace retiring Supreme Court Justice David Souter, she would be the sixth Roman Catholic currently on the court, the New York Times reports. According to the Times, although Sotomayor was raised Catholic and attended a Catholic high school, she appears to be in line with the majority of U.S. Catholics who identify themselves with the faith but do not regularly go to Mass or become heavily involved in religious life. Several studies have shown that Catholics who rarely or never attend mass are more liberal on political and cultural issues than those who attend more regularly, the Times reports. For example, a Gallup poll released in March found that 52% of Catholics who do not attend church regularly say abortion is morally acceptable, compared with 24% of Catholics that are regular churchgoers. A White House spokesperson said that Sotomayor "currently does not belongs to a particular parish or church, but she attends church with family and friends for important occasions" (Goodstein, New York Times, 5/31).According to the Boston Globe, the number of Catholics on the court has increased sharply over the past two decades, a shift from earlier years when there generally was one "Catholic seat" on the bench. Although Supreme Court experts say that the increase in the number of Catholic justices reflects a fall in anti-Catholicism over the past half-century, they also note that Catholic justices" views have not always aligned with the Church"s teachings and that a judge"s faith is not necessarily an indicator of how he or she will rule on issues like abortion rights or gay marriage. Current Catholic Supreme Court Justices Clarence Thomas, Antonin Scalia, Anthony Kennedy, Samuel Alito and Chief Justice John Roberts all are in favor of either overturning Roe v. Wade or returning the issue of abortion to the states, the Globe reports. However, there have been previous Catholic justices, such as Justice William Brennan, who were avid supporters of abortion rights (Paulson, Boston Globe, 5/30).Cathleen Kaveny, a professor of law and theology at the University of Notre Dame, said, "I don"t think there is any one Catholic stance on the law," adding, "You"ll have judges who are pro-life personally who are going to rule that [Roe] is the law of the land."Sotomayor "Formidable Counterweight" to Catholic Men on Court, Opinion Piece Says "If anyone should be worrying" about Sotomayor as the sixth Catholic on the Supreme Court, "it"s the five who are already there," former Catholics for Free Choice President Frances Kissling writes in a Salon opinion piece. Roberts, Alito, Kennedy, Scalia and Thomas "all seem cut from the same traditional Catholic (and Federalist Society conservative) mold," Kissling writes, noting that all five voted in Gonzales v. Carhart to uphold the Partial-Birth Abortion Ban Act. If confirmed, Sotomayor"s experience with the other justices "is likely to change [her] as well -- and make her an even more formidable counterweight to the male Catholic bloc," according to Kissling. "There is nothing more likely to radicalize a "moderate" Catholic woman of even marginal religiosity than daily exposure to Catholic men who think women need to be protected from making money or making bad and sad abortion choices," Kissling contends (Kissling, Salon, 5/31).
Public Health

Aspirin As A Prophylaxis For Fatal Pulmonary Embolism

A study published provides results which challenge the current NICE guidelines (set in April 2007) relating to the use of low-molecular weight heparin (LMWH) rather than aspirin as a thromboprophylaxis following orthopaedic surgery. Currently the guidance states that LMWH is preferable to aspirin and partly is based on two assumptions that the report"s authors wished to test: that chemical and/or mechanical prophylaxis will reduce these complications and that orthopaedic operations, in particular elective hip and knee replacements, are high-risk. The study analysed over 4,000 patients undergoing primary joint replacement, the majority of whom received aspirin only as a chemical prophylaxis. The overall death rate was 0.31% and the rate of fatal pulmonary embolism was 0.07%, while the overall mortality rate in the general population for gender and age matched controls was 50% more than those undergoing surgery. Therefore, the report"s authors conclude that "it does seem unlikely that the adoption of LMWH could produce any further significant reduction on observed mortality in this patient group". In addition, "the fatal pulmonary embolism rate (0.07%) suggests that this is a rare event even after elective total joint replacement if aspirin is given", meaning that aspirin is an effective thromprophylaxis for patients after orthopaedic surgery. Read the full text article. The Journal of Bone and Joint Surgery


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