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New Tests For The Investigation Of Patients With Painful Metal-on-metal Resurfacing Arthroplasties
This paper investigates 26 patients with painful metal-on-metal resurfacing arthroplasties and describes three tests for the investigation of the phenomenon. The tests are metal artefact-reduction MRI, 3-D CT measurement of the position of the component and inductively-coupled plasma mass spectrometry.
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Report Finds Racial Disparities In Prescription Drug Access, Use, Regimen Adherence
"Origins and Strategies for Addressing Ethnic and Racial Disparities in Pharmaceutical Therapy: The Health-Care System, the Provider, and the Patient," National Minority Quality Forum: The report -- by Richard Levy, a health care consultant and former vice president of the National Pharmaceutical Council; Robert Like, professor and director of the Center for Healthy Families and Cultural Diversity of the UMDNJ-Robert Wood Johnson Medical School; and Harry Shabsin, a private-practice psychologist -- looks at how appropriate medications for a variety of diseases often are under-prescribed, over-prescribed, or mis-prescribed among minorities. The report looks at disparities in treatment of minority patients with cardiovascular disease, asthma, psychiatric illness, pain and other conditions and finds disparities in access to medications through insurance programs, in the prescribing of medications and in adherence to medication regimens. The report offers ways to improve prescribing and use of medications among diverse communities (National Minority Quality Forum release, 5/12).
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Paclitaxel Poliglumex (OPAXIO(TM)) Added To Cisplatin And Radiation Produces 45% Pathologic Complete Remissions In Patients With Esophageal Cancer
Cell Therapeutics, Inc. ("CTI") (Nasdaq and MTA: CTIC) announced that, in a study released from Brown University at the 2009 American Society for Clinical Oncology (ASCO) Annual Meeting, patients with cancer of the lower esophagus had evidence of a high pathological complete response ("CR") rate when given OPAXIO, a biologically enhanced paclitaxel, in addition to cisplatin and full-course radiotherapy.
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Brain Activity Stablilized By Dynamic Molecular Mechanism

In the brain, many types of synaptic proteins are spatio-temporally regulated to maintain synaptic activity at a constant level. Here, the Japanese research group led by Professor Masaki Fukata, Drs. Yuko Fukata and Jun Noritake in National Institute for Physiological Sciences, Japan, found that two types of palmitoylating enzymes finely-tune the location and function of a major synaptic protein, PSD-95, in different ways. They also found that this mechanism contributes to keeping synaptic activity stable when synaptic activity dynamically changes. The Japan Science and Technology Agency (JST) supported this study. They report the finding in Journal of Cell Biology published on July 13, 2009. The research group focused on two types of palmitoylating enzymes, DHHC2 and DHHC3. Protein palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating synaptic proteins in neurons. Here, the research group found that DHHC3 is located in the cell body of neurons to palmitoylate newly synthesized synaptic proteins such as PSD-95, and move out them into dendrites of neurons. In contrast, DHHC2 are located mainly in dendrites of neurons. Dendritically localized DHHC2 mediates dynamic palmitoylation of PSD-95 at synapses upon extracellular signals. When synaptic activity decreases, DHHC2 translocates to the synaptic site to facilitate palmitoylation of synaptic proteins to keep synaptic activity at a constant level. "We have already found 23 types of palmitoylating enzymes. Our finding suggests that individual palmitoylating enzymes have distinct functions in neurons. Some of palmitoylating enzymes are known to be differently related to neurological disorders such as mental retardation, schizophrenia and Huntington"s disease. Therefore, this palmitoylating enzyme family may represent exciting therapeutic targets", said Professor Fukata. Masaki Fukata National Institute for Physiological Sciences


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