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Exenatide Once Weekly Provided Superior Glucose Control Compared To Lantus(R) In Head-to-Head DURATION-3 Study
Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN), Eli Lilly and Company (NYSE: LLY) and Alkermes, Inc. (Nasdaq: ALKS) today announced positive results from a study comparing subjects randomized to either exenatide once weekly or Lantus® (insulin glargine). Patients randomized to exenatide once weekly experienced a statistically superior reduction in A1C, a measure of average blood sugar over three months, of 1.5 percentage points from baseline, compared to a reduction of 1.3 percentage points for Lantus after completing 26 weeks of treatment. At the end of the study, patients treated with exenatide once weekly achieved a mean A1C of 6.8 percent compared with a mean A1C of 7.0 percent in those treated with Lantus. Treatment with exenatide once weekly also produced a statistically significant difference in weight, with a mean weight loss of 5.8 pounds at 26 weeks, compared with a mean weight gain of 3.1 pounds for Lantus, a difference of 8.9 pounds between the treatments.
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Advance In Detecting Melamine-adulterated Food
Researchers in Indiana are reporting an advance toward faster, more sensitive tests for detecting melamine, the substance that killed at least 6 children and sickened 300,000 children in China who drank milk and infant formula adulterated with the substance. The improved tests may ease global concerns about food safety, the researchers say. Their report is scheduled for the May 27 issue of ACS" Journal of Agricultural and Food Chemistry, a bi-weekly publication.
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Review: Weak Support For Workplace Hearing Loss Programs
A new review of existing research says there is little evidence to support mandatory hearing-loss prevention programs at the workplace.
Oncology

Can Tribble 3 Can Induce Non-Alcoholic Fatty Liver Disease?

Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance. This research, lead by Dr. Yu-Gang Wang and his colleagues in the Department of Gastroenterology, Shanghai Changning Central Hospital, China, used real-time fluorescent quantitative reverse transcription-polymerase chain reaction technology and Western blotting analysis to study the protein expression of TRB3mRNA, Akt and phosphorylation protein kinase B during the progression of NAFLD. The expression level of TRB3mRNA in NAFLD rats was significantly higher than in normal controls. Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD. This study provides an experimental basis for future studies on the role of TRB3 in NAFLD. The control of the expression level of TRB3 in liver may become a new target for NAFLD therapy. Reference: Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2009; 15(19): 2329-2335 Correspondence to: Dr. Xi-Mei Chen, Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China. Jian-Xia Cheng World Journal of Gastroenterology


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