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Perception Of Unsafe Neighborhoods Disables The Elderly
Elderly people who live below the poverty line and perceive their neighborhoods to be dangerous are more likely to have a mobility disability. Researchers writing in the open access journal BMC Public Health suggest that even perceiving one"s neighborhood as unsafe can "get into the body" and, ultimately, prove hazardous for elder health.
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Malaysian Surgeons To Learn Piles Management From Prof Rama Kant
The Department of Surgery, University of Malaya Medical Centre (UMMC) in Kuala Lumpur, Malaysia has invited noted Surgeon Professor (Dr) Rama Kant, Head of Surgery Department at Chhattrapati Shahuji Maharaj Medical University (CSMMU) to deliver a talk on haemorrhoids (piles).
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Presentation At AAPM Meeting On Nanoparticles That Package Cancer-killing Isotopes And Deliver Them Into Cancer Cells
A group of researchers at Johns Hopkins University has designed nanoparticles that can carry cancer-treating radioisotopes through the body and deliver them selectively to tumors. Today in Anaheim, CA, they will report the latest results of their research, including studies in animal models, at the 51st meeting of the American Association of Physicists in Medicine (AAPM).
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Can Tribble 3 Can Induce Non-Alcoholic Fatty Liver Disease?

Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance. This research, lead by Dr. Yu-Gang Wang and his colleagues in the Department of Gastroenterology, Shanghai Changning Central Hospital, China, used real-time fluorescent quantitative reverse transcription-polymerase chain reaction technology and Western blotting analysis to study the protein expression of TRB3mRNA, Akt and phosphorylation protein kinase B during the progression of NAFLD. The expression level of TRB3mRNA in NAFLD rats was significantly higher than in normal controls. Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD. This study provides an experimental basis for future studies on the role of TRB3 in NAFLD. The control of the expression level of TRB3 in liver may become a new target for NAFLD therapy. Reference: Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2009; 15(19): 2329-2335 Correspondence to: Dr. Xi-Mei Chen, Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China. Jian-Xia Cheng World Journal of Gastroenterology


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