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IMPACT Study Shows Longer Valcyte Treatment Provides Better Protection Against Cytomegalovirus (CMV) Disease
New Phase III study results presented for the first time today at the ninth annual American Transplant Congress 2009 (ATC) demonstrate that doubling the duration of preventive therapy ("prophylaxis") with Valcyte (oral valganciclovir), significantly reduces the incidence of CMV disease by 56% in high-risk kidney transplant patients within the first year post-transplant.(1)
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Discovery Of Breast Cancer Gene That's Blocked By Blood Pressure Drug
Researchers have identified a gene that is overexpressed in up to 20 percent of breast cancers and that could be blocked in the lab by a currently available blood pressure drug, according to a new study from the University of Michigan Comprehensive Cancer Center.
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Study Provides Greater Understanding Of Lyme Disease-Causing Bacteria
Lyme disease in the U.S. is caused by the tick-borne bacteria Borrelia burgdorferi and usually begins with a skin lesion, after which the bacteria spread throughout the body to the nervous system, heart or joints. About 60 percent of untreated individuals develop arthritis, which affects the knees in particular. Lyme disease usually responds well to antibiotic therapy, but in rare cases arthritis can persist for months or years after treatment, a rare condition known as antibiotic-refractory Lyme arthritis. Joint fluid usually tests negative for B burgdorferi after treatment, indicating that joint inflammation may persist even after the bacteria has been eradicated.
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Children's Hospital Of Pittsburgh Of UPMC Biologist Receives Prestigious Fellowship Award

John F. Alcorn, Ph.D., a biologist in the John G. Rangos Sr. Research Center at Children"s Hospital of Pittsburgh of UPMC, has been selected as one of ten 2009 recipients of the prestigious Parker B. Francis Fellowship, awarded each year to scientists conducting pulmonology research. Dr. Alcorn"s research focuses on uncovering the molecular pathway of pneumonia infections and defining novel therapeutic targets in the lung. His studies will address the role of helper T cells and their downstream signaling pathways involved in host defense, all of which will promote the resolution of pneumonia. "The lung is exposed to many external pathogens, including bacteria, with every breath," Dr. Alcorn said, "and despite a vast amount of research, we still do not fully understand the disease mechanisms of pneumonia." Dr. Alcorn, a native of Brookville, Pa., completed his Bachelor and Master of Science degrees at Youngstown State University. He earned a doctorate in cell and molecular biology from Duke University in 2003 and completed his postdoctoral fellowship at the University of Vermont. Renowned for its outstanding clinical services, research programs and medical education, Children"s Hospital of Pittsburgh of UPMC has helped establish the standards of excellence in pediatric care. From ambulatory care to transplantation and cardiac care, talented and committed pediatric experts care for infants, children and adolescents who make more than 500,000 visits to Children"s and its many neighborhood locations each year. Children"s also has been named consistently to several elite lists of pediatric health care facilities, including ranking eighth among children"s hospitals (FY 2006) in funding provided by the National Institutes of Health, and is named one of the top pediatric hospitals in the United States by U.S. News & World Report. The Parker B. Francis Fellowship program enables researchers to devote a major part of their professional careers to research related to pulmonary disease and lung biology. The three-year fellowship provides $156,000 to each recipient in support of his or her research. In 1951, Parker B. Francis, founder of the Puritan-Bennett Company, established a foundation bearing his name in Kansas City, Mo. Since Puritan-Bennett was a leading manufacturer of respiratory equipment and medical gases, the primary emphasis of the foundation was related to pulmonary research. Today, the Francis Family Foundation remains the sole benefactor of the Parker B. Francis Fellowship Program, in addition to supporting educational and cultural programs geographically located within the Greater Kansas City area. Since 1976, the foundation has contributed more than $50 million to the fellowship program in support of more than 750 fellows. UPMC


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