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ReachMD Launches CME iPhone APP
ReachMD, which provides medical news and information to healthcare practitioners, is raising its profile with the Continuing Medical Education, or CME, application for the Apple iPhone and iPod touch. This is the first CME application that lets users listen to all ReachMD Continuing Medical Education content, get regular updates on new Continuing Medical Education content and take Continuing Medical Education tests for credit, all from their iPhone or iPod touch.
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Micromet Presents Update On Blinatumomab's Response Rate And Duration In A Phase 1 Study In Non-Hodgkin's Lymphoma Patients
Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, last week presented an update from an ongoing clinical study of the BiTE(R) antibody blinatumomab (MT103) for non-Hodgkin"s lymphoma (NHL) at the 14th Congress of the European Hematology Association (EHA), held June 4 to 7 in Berlin, Germany. Blinatumomab is a novel therapeutic antibody that activates a patient"s T cells to seek out and destroy cancer cells.
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White Matter Changes May Predict Dementia Risk
Elderly people with no memory or thinking problems are more likely to later develop thinking problems if they have a growing amount of "brain rust," or small areas of brain damage, according to a study published in the July 14, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Public Health

Confirmed Link Between Chronic Infection And Immune-System Protein

The reason deadly infections like human immunodeficiency virus (HIV) and hepatitis C never go away is because these viruses disarm the body"s defense system. Researchers at the University of Alabama at Birmingham (UAB) have discovered that a key immunity protein must be present for this defense system to have a chance against chronic infection. Research up to now has tried but failed to decipher the cross-talk between "killer T-cells" and "helper T-cells" in the fight against viruses. The new UAB study finds this cross-talk can only happen in the presence of interleukin-21, a powerful immune system protein. If interleukin-21 is missing for whatever reason, then the immune system"s anti-viral efforts fail, said Allan Zajac, Ph.D., an associate professor in UAB"s Department of Microbiology and lead author on the study. The findings are published in the journal Science through its Science Express service. "Adding interleukin-21 back in stimulates the immune response and controls the infection," Zajac said. "We demonstrate that the loss of this protein prevents the control of the infection and diminishes the function of the killer T-cells, specifically CD8 T-cells." The study mice were treated for lymphocytic choriomeningitis, a viral infection of the membranes surrounding the brain and spinal cord. Measurements were taken for two types of T-cells, CD4 and CD8 T-cells, before and after the mice were treated with interleukin-21. "Interleukin-21 served as the key messenger between the T-cells, whereas before we didn"t know exactly how the two types of cells communicated with each other," Zajac said. The CD4 T-cells help the immune system do its job by boosting CD8 T-cells" ability to fight and kill viruses. Co-authors on the study include John Yi and Ming Du, Ph.D., both of UAB"s Department of Microbiology. Research funds came from the National Institutes of Health. Troy Goodman University of Alabama at Birmingham


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