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Three Rivers Announces Positive Results From Phase 3 DIRECT Trial Of Once-Daily INFERGEN(R) With Ribavirin In Hepatitis C Virus Treatment Failures
Three Rivers Pharmaceuticals announced positive results of the U.S.-based, randomized Daily-Dose Consensus Interferon and Ribavirin: Efficacy of Combined Therapy (DIRECT) clinical trial authored by Bruce R. Bacon, M.D., of Saint Louis University, and colleagues at 44 centers in the United States. The primary endpoint of increased sustained virological response (SVR), was achieved demonstrating that INFERGEN provides a second chance to those HCV patients failing to respond to standard, first-line therapy of pegylated interferon (PEG-IFN) plus ribavirin (RBV). "The retreatment of PEG-IFN/RBV nonresponders with INFERGEN and RBV is safe and efficacious and can be considered a retreatment strategy for patients failing previous therapy with PEG-IFN/RBV, especially in interferon-sensitive patients with lower baseline fibrosis scores," stated Dr. Bruce Bacon the lead Investigator for the study.
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Research In The Bolivian Rainforest Suggests Ancient, Shared Roots Of Feeding Behaviours In Monkeys And Humans
Behavioural ecologists working in Bolivia have found that wild spider monkeys control their diets in a similar way to humans, contrary to what has been thought up to now. Rather than trying to maximize their daily energy intake, the monkeys tightly regulate their daily protein intake, so that it stays at the same level regardless of seasonal variation in the availability of different foods.
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Supreme Court Nominee Sotomayor Would Be Sixth Catholic On Bench
If Judge Sonia Sotomayor is confirmed to replace retiring Supreme Court Justice David Souter, she would be the sixth Roman Catholic currently on the court, the New York Times reports. According to the Times, although Sotomayor was raised Catholic and attended a Catholic high school, she appears to be in line with the majority of U.S. Catholics who identify themselves with the faith but do not regularly go to Mass or become heavily involved in religious life. Several studies have shown that Catholics who rarely or never attend mass are more liberal on political and cultural issues than those who attend more regularly, the Times reports. For example, a Gallup poll released in March found that 52% of Catholics who do not attend church regularly say abortion is morally acceptable, compared with 24% of Catholics that are regular churchgoers. A White House spokesperson said that Sotomayor "currently does not belongs to a particular parish or church, but she attends church with family and friends for important occasions" (Goodstein, New York Times, 5/31).According to the Boston Globe, the number of Catholics on the court has increased sharply over the past two decades, a shift from earlier years when there generally was one "Catholic seat" on the bench. Although Supreme Court experts say that the increase in the number of Catholic justices reflects a fall in anti-Catholicism over the past half-century, they also note that Catholic justices" views have not always aligned with the Church"s teachings and that a judge"s faith is not necessarily an indicator of how he or she will rule on issues like abortion rights or gay marriage. Current Catholic Supreme Court Justices Clarence Thomas, Antonin Scalia, Anthony Kennedy, Samuel Alito and Chief Justice John Roberts all are in favor of either overturning Roe v. Wade or returning the issue of abortion to the states, the Globe reports. However, there have been previous Catholic justices, such as Justice William Brennan, who were avid supporters of abortion rights (Paulson, Boston Globe, 5/30).Cathleen Kaveny, a professor of law and theology at the University of Notre Dame, said, "I don"t think there is any one Catholic stance on the law," adding, "You"ll have judges who are pro-life personally who are going to rule that [Roe] is the law of the land."Sotomayor "Formidable Counterweight" to Catholic Men on Court, Opinion Piece Says "If anyone should be worrying" about Sotomayor as the sixth Catholic on the Supreme Court, "it"s the five who are already there," former Catholics for Free Choice President Frances Kissling writes in a Salon opinion piece. Roberts, Alito, Kennedy, Scalia and Thomas "all seem cut from the same traditional Catholic (and Federalist Society conservative) mold," Kissling writes, noting that all five voted in Gonzales v. Carhart to uphold the Partial-Birth Abortion Ban Act. If confirmed, Sotomayor"s experience with the other justices "is likely to change [her] as well -- and make her an even more formidable counterweight to the male Catholic bloc," according to Kissling. "There is nothing more likely to radicalize a "moderate" Catholic woman of even marginal religiosity than daily exposure to Catholic men who think women need to be protected from making money or making bad and sad abortion choices," Kissling contends (Kissling, Salon, 5/31).
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Enzyme Important In Aging Identified By Scientists At Children's Hospital Of Pittsburgh Of UPMC

The secret to longevity may lie in an enzyme with the ability to promote a robust immune system into old age by maintaining the function of the thymus throughout life, according to researchers studying an "anti-aging" mouse model that lives longer than a typical mouse. The study, led by Abbe de Vallejo, Ph.D., associate professor of pediatrics and immunology, University of Pittsburgh School of Medicine, and immunologist at Children"s Hospital of Pittsburgh of UPMC, reports that the novel mouse model has a thymus that remains intact throughout its life. In all mammals, the thymus - the organ that produces T cells to fight disease and infection - degenerates with age. Results of the study are published in this week"s issue of the Proceedings of the National Academy of Sciences. "These findings give us hope that we may one day have the ability to restore the function of the thymus in old age, or perhaps by intervening at an early age, we may be able to delay or even prevent the degeneration of the thymus in order to maintain our immune defenses throughout life," said Dr. de Vallejo. The mouse model that Dr. de Vallejo"s team studied was developed by his colleague Cheryl Conover, Ph.D., an endocrinology researcher at Mayo Clinic. In this "knockout" mouse model, researchers deleted an enzyme known as pregnancy-associated plasma protein A (PAPPA). PAPPA-knockout mice live at least 30 percent longer and have significantly lower occurrence of spontaneous tumors than typical mice. PAPPA controls the availability in tissues of a hormone known as insulin-like growth factor (IGF) that is a promoter of cell division. Hence, IGF is required for normal embryonic and postnatal growth. But IGF also is associated with tumor growth, inflammation and cardiovascular disease in adults. By deleting PAPPA, the researchers were able to control the availability of IGF in tissues and dampen its many ill effects. In the thymus, deletion of PAPPA maintained just enough IGF to sustain production of T cells without consuming precursor cells, thereby preventing the degeneration of the thymus. "Controlling the availability of IGF in the thymus by targeted manipulation of PAPPA could be a way to maintain immune protection throughout life," Dr. de Vallejo said. "This study has profound implications for the future study of healthy aging and longevity." Marc Lukasiak University of Pittsburgh Schools of the Health Sciences


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