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Less Frequent Social Activity May Be Associated With Motor Function Decline In Older Adults
Among older adults, less frequent participation in social activity is associated with a more rapid rate of motor function decline, according to a report in the June 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
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Research Scientists Discover How Flu Damages Lung Tissue
A protein in influenza virus that helps it multiply also damages lung epithelial cells, causing fluid buildup in the lungs, according to new research from the University of Alabama at Birmingham (UAB) and Southern Research Institute . Publishing online this week in the journal of the Federation of American Societies for Experimental Biology, the researchers say the findings give new insight into how flu attacks the lungs and provides targets for new treatments.
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Many Washington State Hospitals Skimp On Required Charity Care
"As the recession has cost more people their jobs and their health insurance, local hospitals have seen more patients show up with no way to pay," reports KUOW, a Washington State public radio station. "Hospitals in Washington are required to provide free care to anyone living below the poverty line, if they ask for it. But some hospitals give more freely than others."
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International Collaboration By Scientists Culminates In Novel Ion Channels Database

An important re consolidating understanding of the roles played by Ion channels in drug action is now available for scientists and students. The International Union of Basic and Clinical Pharmacology (IUPHAR) announce the publication of a new ion channels database, covering both the voltage-gated (VGIC) and ligand-gated (LGIC) ion channels. This represents a major addition to its existing mammalian receptor database, which is freely available here. The IUPHAR database, hosted by the Centre for Cardiovascular Science at University of Edinburgh, is a carefully curated and authoritative re drawing together peer reviewed information about pharmacological, chemical, genetic, functional and patho-physiological properties of human, rat and mouse genes encoding in excess of 354 non sensory G protein-coupled receptors (GPCRs) including orphan receptors, 71 LGIC and 141 VGIC subunits. This set of genes is known to encompass a third of current drug targets and a significant proportion of likely targets for the development of future medicines. In keeping with the database"s tradition, many leading research pharmacologists were closely involved in the data curation process, with Professors William A. Catterall (University of Washington) and George Gutman (University of California) taking leading roles for VGICs and Professors John A. Peters (The University of Dundee) and Richard Olsen (University of California, Los Angeles) for the LGICs. The IUPHAR database is a major online reference re and first-port-of-call for information about mammalian drug targets for students and scientists throughout the world, attracting approximately 2500 unique visitors to its website each week from 130 countries. In this current release of receptor families, IUPHAR provides detailed information for 8 VGIC and 3 LGIC families. Curation of the remaining five ion channel gene families is underway. The ion channel database is now available here. IUPHAR also remains committed to the ongoing update of the GPCR database which has been publicly available since 2005. GPCR pages updated in the current release are melanin-concentrating hormone, estrogen and P2Y receptors. Chido Mpamhanga University of Edinburgh


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