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Silenced Genes As A Warning Sign Of Blood Cancer
In many types of cancer, parts of the genetic material of tumor cells are switched off by chemical labels called methyl groups. This kind of methyl labeling ranges among the epigenetic changes that do not change the sequence of DNA building blocks. Such labels are found particularly often in genes which act as important inhibitors of pathogenic cell growth.
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200 Percent Increase In Cardiovascular Medication In Canada
A new study in the Canadian Medical Association Journal (CMAJ) reports that the number of prescriptions in Canada for cardiovascular medications has been increasing over the last ten years. There has been a 200 percent increase in costs. Overall costs of cardiovascular medications exceeded $5 billion in 2006. And statins accounted for nearly 40 percent of the expenditure.
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DCP Comments On New Horizons - British Psychological Society
The British Psychological Society has welcomed the publication, of New Horizons, the government"s new plan for the development of mental health services.
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International Collaboration By Scientists Culminates In Novel Ion Channels Database

An important re consolidating understanding of the roles played by Ion channels in drug action is now available for scientists and students. The International Union of Basic and Clinical Pharmacology (IUPHAR) announce the publication of a new ion channels database, covering both the voltage-gated (VGIC) and ligand-gated (LGIC) ion channels. This represents a major addition to its existing mammalian receptor database, which is freely available here. The IUPHAR database, hosted by the Centre for Cardiovascular Science at University of Edinburgh, is a carefully curated and authoritative re drawing together peer reviewed information about pharmacological, chemical, genetic, functional and patho-physiological properties of human, rat and mouse genes encoding in excess of 354 non sensory G protein-coupled receptors (GPCRs) including orphan receptors, 71 LGIC and 141 VGIC subunits. This set of genes is known to encompass a third of current drug targets and a significant proportion of likely targets for the development of future medicines. In keeping with the database"s tradition, many leading research pharmacologists were closely involved in the data curation process, with Professors William A. Catterall (University of Washington) and George Gutman (University of California) taking leading roles for VGICs and Professors John A. Peters (The University of Dundee) and Richard Olsen (University of California, Los Angeles) for the LGICs. The IUPHAR database is a major online reference re and first-port-of-call for information about mammalian drug targets for students and scientists throughout the world, attracting approximately 2500 unique visitors to its website each week from 130 countries. In this current release of receptor families, IUPHAR provides detailed information for 8 VGIC and 3 LGIC families. Curation of the remaining five ion channel gene families is underway. The ion channel database is now available here. IUPHAR also remains committed to the ongoing update of the GPCR database which has been publicly available since 2005. GPCR pages updated in the current release are melanin-concentrating hormone, estrogen and P2Y receptors. Chido Mpamhanga University of Edinburgh


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