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TR BioSurgical, LLC Develops Breakthrough Osteoarthritis Implant
TR BioSurgical, LLC, announced highly encouraging results using their new medical device (bioscaffold) in canine patients with advanced osteoarthritis. The new bioscaffold is implanted in or near diseased tissue and provides a structural matrix for local repair cells, such as stem cells or fibroblasts, to attach and heal tissue by local, physiological repair mechanisms. The new bioscaffold implant contains no drugs, cells or growth factors and is eventually resorbed by the infiltrating cells. The implant is made from a proprietary, copolymerized collagen and is sterile, cost effective, and non- immunogenic.
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Sugar Substitute Appears To Prevent Early-Childhood Cavities
Children given an oral syrup containing the naturally occurring sweetener xylitol may be less likely to develop decay in their baby teeth, according to a report in the July issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
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What Is The Function Of Lymph Nodes?
If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations - the regions in which the immune response is organised. However, a new paper - published in this week"s issue of PLoS Biology - suggests that lymph nodes are not essential in the mouse in marshalling T-cells (a main immune foot soldier) to respond to a breach of the skin barrier. This result is both surprising in itself, and suggests a novel function for the liver as an alternate site for T-cell activation.
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Link Between Pancreatic Cancer And Dietary Fat

High intake of dietary fats from red meat and dairy products was associated with an increased risk of pancreatic cancer, according to a new study published online June 26 in the Journal of the National Cancer Institute. This study was undertaken because research relating fat intake to pancreatic cancer was inconclusive. To examine the association, Rachael Z. Stolzenberg-Solomon, Ph.D., of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute in Bethesda, Md., and colleagues analyzed a cohort of over 500,000 people from the National Institutes of Health - AARP Diet and Health Study. Participants completed a food frequency questionnaire in 1995 and 1996 and were followed prospectively for an average of 6 years to track a variety of health outcomes, including pancreatic cancer. Men and women who consumed high amounts of total fats had 53% and 23% higher relative rates of pancreatic cancer, respectively, compared with men and women who had the lowest fat consumption. Participants who consumed high amounts of saturated fats had 36% higher relative rates of pancreatic cancer compared with those who consumed low amounts. "[W]e observed positive associations between pancreatic cancer and intakes of total, saturated, and monounsaturated fat overall, particularly from red meat and dairy food s. We did not observe any consistent association with polyunsaturated or fat from plant food s," the authors write. "Altogether, these results suggest a role for animal fat in pancreatic carcinogenesis." In an accompanying editorial, Brian M. Wolpin, M.D., MPH, of the Dana Farber Cancer Institute in Boston and Meir J. Stampfer, M.D., DrPH, of the Harvard School of Public Health, call the study well-performed and a good addition to the understanding of pancreatic cancer. They do note, however, that there is insufficient epidemiological and laboratory evidence to confirm the importance of animal fats or even that meat is the important factor, as opposed to other dietary or lifestyle preferences associated with meat consumption. "[W]ith further investigation, this work has the potential to provide interesting clues to the mechanisms underlying pancreatic tumorigenesis," the editorialists write. Citations: Article: Theibaut et al. Dietary Fatty Acids and Pancreatic Cancer in the NIH-AARP Diet and Health Study. J Natl Cancer Inst 2009, 101: 1001-1011. Editorial: Wolpin B and Stampfer M. D. Defining Determinants of Pancreatic Cancer Risk: Are We Making Progress. J Natl Cancer Inst 2009, 101: 972-973. Steve Graff Journal of the National Cancer Institute


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