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Denosumab Demonstrates Superiority Over Zometa(R) In Pivotal Phase 3 Head-to-Head Trial In Breast Cancer Patients With Bone Metastases
Amgen (Nasdaq: AMGN) announced that a pivotal, Phase 3, head-to-head trial evaluating denosumab versus Zometa(R) (zoledronic acid) in the treatment of bone metastases in 2,049 patients with advanced breast cancer met its primary and secondary endpoints and demonstrated superior efficacy compared to Zometa. Superiority was demonstrated for both delaying the time to the first on-study Skeletal Related Events (SREs)(fracture, radiation to bone, surgery to bone, or spinal cord compression) (hazard ratio 0.82, 95 percent CI: 0.71, 0.95), and delaying the time to the first-and-subsequent SREs (hazard ratio 0.77, 95 percent CI: 0.66, 0.89). Both results were statistically significant.
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My Prostate Cancer Operation - A Personal Diary
This is a personal account of my battle so far with prostate cancer. My name is Christian Nordqvist, 53, Editor of Medical News Today. On 26th of March, 2009, I underwent a radical prostatectomy - in other words, I had my prostate taken out. A biopsy had detected cancerous tissue in the prostate. Before that, a routine check-up had revealed higher than normal levels of PSA in my blood. After discussing various options with my urologist, we decided that radical prostatectomy was best for me. There were two compelling reasons for this - I am 53 (relatively young for this type of disease), and I have a family history of prostate cancer.
News of the day
For Doctors And Even Patients, Rationing Health Care Is An Everyday Occurrence
In an essay in The Washington Post, an infectious disease specialist writes that "the unspoken truth among doctors is that we objectively or subjectively ration care, and often don"t tell patients or their families." Organs, for example, "are a precious commodity, their donation strictly regulated by national guidelines. ò€¦ Because donors are scarce, it seems appropriate to ration their organs on the basis of need and other ethical and medical considerations." Medical care is also rationed through long wait times to see physicians (ranging from 11 to 50 days in major cities, according to a 2009 survey by Merritt Hawkins & Associates) or shortages of beds in a hospital.
Public Health

Meeting To Examine Human Behavior And The Threat Of Disease

As swine flu spread from Mexico to Texas and then fanned out farther in the United States, Americans began to alter their behavior. Families kept children home from school, postponed trips to the mall, and stayed home instead of eating out. In so doing, the American population may have inadvertently altered the behavior of the pathogen itself. How human behavior changes the spread of emerging infectious diseases, and how the spread of disease simultaneously changes human behavior, will be among the topics discussed by scientists at a meeting at the National Institute for Biological and Mathematical Synthesis (NIMBioS) on the University of Tennessee campus, June 7-9. Ecologists, epidemiologists, economists, and mathematicians will comprise a NIMBioS Working Group to tackle the topic, Synthesizing and Predicting Infectious Disease While Accounting for Endogenous Risk or SPIDER. Accounting for endogenous risk means jointly considering how human behavior influences disease and how disease influences human behavior, explained Eli Fenichel, workshop co-organizer and assistant professor at Arizona State University. "When people perceive risks, they alter their behavior, which in turn, alters the risk. It"s a feedback loop between people, the pathogen, and the risk." Most current attempts to model the risks of emerging infectious diseases look at the disease itself and human behavior. The SPIDER Working Group aims to build on that classic view by also considering the economic impact of human decisions about risk. "Epidemiological science has gotten good at modeling and projecting risk. The next major frontier is how do we manage risk in a cost effective way," Fenichel said. "It"s a way of thinking about how res get allocated to address emerging pathogens like the flu now. For example, if we believe that people will behave in a certain way given certain information sets, we might be able to find better ways to distribute medicine." Another avenue for investigation is how the global food trade system would be affected if it becomes the of a pathogen, Fenichel said. "One of the questions is how do we set up inspections in a cost effective way if we cannot reasonably inspect everything. We need to look at how to best balance the risks and the costs." The group aims to develop predictive models to forecast the risks associated with emerging infectious diseases in humans, livestock, wildlife, and plants, and to collaborate in developing risk management strategies. NIMBioS Working Groups are comprised of 10-15 invited participants and focus on specific questions related to mathematical biology. Each group typically meets two to three times over the course of two years at the Institute. The National Institute for Mathematical and Biological Synthesis (NIMBioS) brings together researchers from around the world to collaborate across disciplinary boundaries to investigate solutions to basic and applied problems in the life sciences. NIMBioS is funded by the National Science Foundation in collaboration with the U.S. Department of Homeland Security and the U.S. Department of Agriculture, with additional support from The University of Tennessee, Knoxville. Jay Mayfield University of Tennessee at Knoxville


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