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Study Offers New Insights Into Morphine-Induced Tolerance And Increased Pain Sensitivity
A study published in the June issue of Anesthesiology has shown that a drug metabolite of the opioid morphine may be a key factor in the paradoxical increased sensitivity to pain caused by chronic morphine use. For the first time, this metabolite (called morphine-6 glucuronide, or M6G) was shown to act independently of the pain receptors typically targeted during morphine administration.
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Celsion And Yakult Honsha Announce Start-up Of Japanese Clinical Trial Sites In Celsion's Global Phase III ThermoDox(R) Trial For Primary Liver Cancer
Celsion Corporation (NASDAQ: CLSN) and Yakult Honsha Co., Ltd. (Tokyo: 2267) announced that Celsion"s global Phase III ThermoDox trial for the treatment of primary liver cancer will be extended to Japan by Yakult"s expertise. This is an important step towards a potential application to market the drug in Japan. Yakult Honsha is the exclusive licensor of Celsion"s ThermoDox in Japan.
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Schumer Preparing Strong Public Plan Option
Sen. Charles Schumer, D-N.Y., a member of the key Senate Finance Committee and advocate for a government-run health insurance plan, said yesterday he would abandon all other possible compromises in favor of immediately creating a public plan that "would operate on "a level playing field" with private insurers," CongressDaily reports. Other proposals have included a plan that would establish health insurance co-ops with government seed money or "trigger" the creation of a public plan only if private insurers fail to meet certain targets for containing costs and improving access.
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Study Gives Clues To Increasing X-Rays' Power

Three-dimensional, real-time X-ray images of patients could be closer to reality because of research recently completed by scientists at the University of Nebraska-Lincoln and a pair of Russian institutes. In a paper to be published in an upcoming edition of Physical Review Letters, UNL Physics and Astronomy Professor Anthony Starace and his colleagues give scientists important clues into how to unleash coherent, high-powered X-rays. "This could be a contributor to a number of innovations," Starace said. Starace"s work focuses on a process called high-harmonic generation, or HHG. X-ray radiation can be created by focusing an optical laser into atoms of gaseous elements - usually low-electron types such as hydrogen, helium, or neon. HHG is the process that creates the energetic X-rays when the laser light interacts with those atoms" electrons, causing the electrons to vibrate rapidly and emit X-rays. But the problem with HHG has been around almost as long as the onset of the method in 1988: The X-ray light produced by the atoms is very weak. In an effort to make the X-rays more powerful, scientists have attempted using higher-powered lasers on the electrons, but success has been limited. "Using longer wavelength lasers is another way to increase the energy output of the atoms," Starace said. "The problem is, the intensity of the radiation (the atoms) produce drops very quickly." Instead of focusing on low-electron atoms like hydrogen and helium, Starace"s group applied HHG theory to heavier (and more rare) gaseous atoms having many electrons - elements such as xenon, argon and krypton. They discovered that the process would unleash high-energy X-rays with relatively high intensity by using longer wavelength lasers (with wavelengths within certain atom-specific ranges) that happen to drive collective electron oscillations of the many-electron atoms. "If you use these rare gases and shine a laser in on them, they"ll emit X-Rays with an intensity that is much, much stronger (than with the simple atoms)," Starace said. "The atomic structure matters." Starace said that unlocking the high-powered X-rays could lead one day, for example, to more powerful and precise X-ray machines. For instance, he said, heart doctors might conduct an exam by scanning a patient and creating a 3D hologram of his or her heart, beating in real time. Nanoscientists, who study the control of matter on an atomic or molecular scale, also may benefit from this finding, Starace said. Someday, the high-intensity X-rays may be used to make 3D images of the microscopic structures with which nanoscientists work. "With nanotechnology, miniaturization is the order of the day," he said. "But nanoscientists obviously could make use of a method to make the structures they"re building and working with more easily visible." The work is sponsored through funding by the National Science Foundation. Starace said NSF"s sponsorship made the collaboration with his Russian colleagues - Mikhail V. Frolov, N.L. Manakov and T.S. Sarantseva of Voronezh State University, and M.Y. Emelin and M.Y. Ryabikin of the Russian Academy of Sciences - possible. Frolov worked with Starace at UNL from 2002-2004 when he was a postdoctoral research associate in the Department of Physics and Astronomy. He has returned to Lincoln a number of times to collaborate with Starace on the HHG research. Frolov is a Ph.D. student of Manakov, with whom Starace has had a decade-long research collaboration that was initiated with support from NSF. Manakov also has an Adjunct Professor of Physics appointment in the UNL Department of Physics and Astronomy. Steve Smith University of Nebraska-Lincoln


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