Oncology
A nationwide vaccination effort in Mozambique helped to slash the number of reported cases of measles in Mozambique in 2008, Health Minister Ivo Garrido said Wednesday when addressing the country"s parliament, Agencia de Informacao de Mocambique/allAfrica.com reports.
U.N. Agencies, NGOs Appeal For $37M For IDPs In Pakistan
On Friday, HIV/AIDS advocates in California will appear at the state Legislature"s Budget Conference Committee hearing to urge lawmakers to block proposed health-related budget cuts, the Bay Area Reporter reports. According to the Reporter, Gov. Arnold Schwarzenegger"s (R) latest budget proposal includes cutting $67.8 million from state HIV programs and an additional $12.3 million from the AIDS Drug Assistance Program. Anne Donnelly of Project Inform said, "We realize we may have to take cuts to our programs. But let"s make sure they are minimized and that we continue to deliver the essential services to those people living with HIV and those also at risk." Next week HIV/AIDS advocates also plan to convene on the steps of the state Capitol to protest the proposed budget cuts (Bajko, Bay Area Reporter, 6/4).
A research team at the Faculty of Odontology at Malmo University in Sweden has discovered two new proteins that are of importance to the survival of bacteria and their colonization of the human body. Besides enhancing our knowledge of the ability of bacteria to spread, the findings may also lead to more effective treatment of endocarditis and infections associated with implants.
Older patients may have to pass on the heartburn drugs to spare their bones from fractures according to a new study.
Researchers from the Keck School of Medicine of the University of Southern California will present new findings at the American Diabetes Association"s scientific sessions June 5 - 9 in New Orleans, LA.
Workplace deaths and injuries have fallen over the past thirty years but thousands still die every year as a result of work related accidents and ill-health.
The Institute for OneWorld Health, the US-based non-profit pharmaceutical company that develops drugs for people with neglected infectious diseases in the developing world, today announced that it has successfully completed its first screening campaign of the Roche proprietary compound library and will select up to 40 new drug leads for further study intended to identify a new treatment for childhood diarrhea.
One in every 3,000 babies is born with an inborn error of metabolism -- a genetic defect that interferes with their ability to process substances like carbohydrates, proteins and fats. Until recently, tests to detect many of these very rare, disabling, and sometimes fatal disorders like fatty acid oxidation disorders were rarely used. If the child died, the cause would be listed as unknown or Sudden Infant Death Syndrome (SIDS). If they survived, they would experience a range of symptoms and medical problems throughout their lives such as delays in development, seizures, difficulty with growth and autistic behavior.
The following is a
GfK Healthcare"s Roper Global Diabetes Program, the definitive global perspective on diabetes, announced today the launch of its enhanced U.S. Diabetes Patient Market Study. Through a modular approach and with tailored reporting, the study offers health care and related companies in the diabetes category access to patient data and market trends from one of the largest surveys of people with diabetes, and the only one projectable to the U.S. population.
The American Diabetes
There are many indications that computer aided surgery has a major role to play in improving results in orthopaedic surgery, says Dr. Stefano Zaffagnini, who has played a pioneering role in the use of this technology and who moderates a symposium on this theme at the Congress of the European Federation of National Associations of Orthopaedics and Traumatology (EFORT), taking place from June 3 to 6 in Vienna, with more than 8,000 participants from around the world. This technology should allow total knee prosthesis using minimally invasive surgery to become a standard procedure within a decade. Osteotomy and hip operations are only two of the many other fields where computer aided surgery can also markedly improve results for patients, experts state at the EFFORT Congress in Vienna.
SRI International, an
An Essay published this week in the open access journal PLoS Medicine
The International Diabetes Federation (IDF) launched its World Diabetes Day campaign under the slogan "Understand diabetes and take control."
A new partnership between NHS Counter Fraud and law firm Capsticks will strengthen support to health bodies seeking to recover NHS funds lost to fraud.
Doctors and other health workers should be more aware of the high risk of eating disorders among people with obsessive compulsive disorder (OCD) and other anxiety disorders.
A new breakthrough in adult stem cell technology has three Texarkana neurosurgeons leading their industry by utilizing concentrated stem cells for spine surgery. The innovative technique is improving the desired results of surgical interventions for back pain. Leading researchers in the orthopedic and spine industry are predicting the latest developments in this field of medicine will become mainstream practice and, potentially, a standard of care for surgical treatments of severe back pain.
CEL-SCI Corporation (NYSE AMEX: CVM) announced that its collaborators at the University of Hawaii reported on data at the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses that would be protective against tuberculosis and have the potential to treat swine and other H1N1 influenzas.
While tobacco use is an ongoing health hazard for the entire population, its consequences for people with developmental or intellectual disabilities can be especially severe. And the medical community often tends to overlook the tobacco-related burdens these people face. An extensive review of published research on this topic appears in the June edition of the journal Intellectual and Developmental Disabilities.
For patients with the most common form of hepatitis C, the addition of a hepatitis C specific protease inhibitor called telaprevir to the current standard therapy can significantly improve the chances of being cured, and it does it in half the time of standard therapy alone.
Ultrasound examination of the carotid artery is a patient-friendly and inexpensive method for assessing atherosclerosis and thereby predicting the risk of cardiovascular diseases. Peter Holdfeldt, who recently defended his doctoral thesis at Chalmers University of Technology in Sweden, has developed new analytical methods for ultrasound images that can provide more reliable and more exact assessments of atherosclerosis.
The axon is a part of the neuron through which nerve impulses are transmitted, and at the end of which is located the synapse, which connects it to another neuron. In the event of a lesion, the axon is the component which must be regenerated in order to restore the connections between the different neurons and re-form the nerve.
On the 4th June, the Faculty of Health Sciences at the University of Copenhagen will open the doors of its new research center, The Novo Nordisk Foundation Center for Protein Research. The Center is the result of a historic donation from the Novo Nordisk Foundation, which in 2007 gave the University 80 million euros for its establishment.
UroToday.com - Together with Drs. Heruti, Bechor, Justo and Galor, we studied 815 Israeli male adults of whom 305 had complete data and were included in the statistical analysis. In the analyzed population, 2.1% of people without erectile dysfunction (ED) had advanced periodontal disease (defined as recession of periodontal bone of 6 mm or more) in comparison to 9.8% of the mild ED and 15.8% of the moderate/severe ED populations, respectively. However, due to the relatively small groups, we could not present the odds ratio. We are now planning a large-scale study to further establish the association between the two conditions.
Versartis, Inc., a new company developing novel biologics with enhanced properties for patients with metabolic diseases, published abstracts for preclinical data on its two product candidates, VRS-859 (exenatide-rPEG) and VRS-808 (glucagon-rPEG), at the American Diabetes Association Scientific Sessions annual meeting in New Orleans.
A new Faculty of Translational Medicine has been launched to increase support for, and enhance collaboration among researchers as they search for new treatments and diagnostic tests for a range of diseases and conditions. The Faculty is based in the National Institute for Health Research Comprehensive Biomedical Research Center at Guy"s and St Thomas" hospitals and King"s College London.
In the sense that organisms existing today are connected through a chain of life - through their parents, grandparents and other ancestors - almost a billion years back to the first animals of the pre-Cambrian era, an animal"s reproductive cells can be considered to be immortal. These germline cells generate their offspring"s somatic cells - other cells involved in all aspects of growth, metabolism and behavior, which have a set lifespan - and new germline cells that continue on, generation after generation.
The following are based on abstracts or posters to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida, May 29 - June 2, 2008.
WHAT:
The NMC has started work to improve its advice and information on whistle-blowing for nurses and midwives.
"Ameritas believes strongly in the importance of preventive care and oral wellness education," said Roxann Brennfoerder, vice president - group customer relations and operations. Using new technology along with conventional visual exams, this simple screening makes it easier for dentists to detect oral cancer sooner, allowing patients to seek treatment sooner.
The decriminalisation of dispensing errors is an issue that has united the profession.
In 2007, before the current economic downturn, an American family filed for bankruptcy in the aftermath of illness every 90 seconds; three-quarters of them were insured. Over 60% of all bankruptcies in the United States in 2007 were driven by medical incidents. In an article published in the August 2009 issue of The American Journal of Medicine, the results of the first-ever national random-sample survey of bankruptcy filers shows that illnesses and medical bills contribute to a large and increasing share of bankruptcies. The share of bankruptcies attributable to medical problems rose by 50% between 2001 and 2007
Patients with symptoms of stroke or transient ischemic attack (TIA or brain attack) are missing out on potentially life saving treatment because they are routinely considered by the NHS as low priority cases. Instead of being fast-tracked into hospital for surgery the vast majority of patients are spending weeks and sometimes months on poorly managed referral pathways with the risk of going on to have more severe strokes.
In an effort to foster global biomedical research that will ultimately lead to new and improved treatments for patients with blood diseases, the American Society of Hematology (ASH) and the European Hematology Association (EHA) have collaborated to create the Translational Research Training in Hematology (TRTH) program. This program will provide promising translational investigators an opportunity to undertake intensive training in the causes, diagnosis, and experimental treatment of hematologic disorders from some of the most recognized names in the field.
The Pest Management Regulatory Agency of Health Canada has granted Innovotech (TSV VENTURE:IOT) a Research Authorization for large-scale field trials for the 2009 season to test its novel seed treatment, AgressTM. This Research Authorization provides growers with an opportunity to assess the real-world ability of AgressTM to fight bacterial disease and its ease of use. In conjunction with cooperating growers, dry beans treated with AgressTM have been planted on farms in Alberta.
Cystitis refers to inflammation of the lining of the bladder. It usually occurs when the normally sterile urethra and bladder (lower urinary tract) are infected by bacteria and become irritated and inflamed. Cystitis is fairly common and can affect both men and women and people of all ages. However, it is more common in women.
The American Society of Echocardiography (ASE) welcomes the world"s leading researchers in cardiovascular medicine to present their most-recent findings at its 20th Annual Scientific Sessions, June 6-10, at the Gaylord National Convention Center in Washington, DC. This year, NBA basketball player and former heart patient, Ronny Turiaf will be in attendance to talk about how echocardiography, otherwise known as heart ultrasound, saved his life.
What
Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, last week presented an update from an ongoing clinical study of the BiTE(R) antibody blinatumomab (MT103) for non-Hodgkin"s lymphoma (NHL) at the 14th Congress of the European Hematology Association (EHA), held June 4 to 7 in Berlin, Germany. Blinatumomab is a novel therapeutic antibody that activates a patient"s T cells to seek out and destroy cancer cells.
BioVex Inc, a company developing next generation biologics for the treatment and prevention of cancer and infectious disease, announced that the results from a Phase I/II combination study in previously untreated patients with head and neck cancer will be presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting, which will take place May 29, 2009 - June 2, 2009 in Orlando, FL.
The St. Petersburg Times examines the work of Paul Farmer - "the Harvard-educated doctor who, starting in Haiti, built a multinational organization on the radical idea that poor patients deserve the same care as rich ones" and is reportedly being considered for a high-level job with USAID or the State Department. The newspaper reports that though it"s "not a sure thing, even his candidacy indicates how far the international aid establishment has come around to Farmer"s way of thinking, health care experts say."
Tau protein tangles are found in the brains of people with a range of neurodegenerative diseases, including Alzheimer"s.
Known for his often controversial approach to public health issues, Dr. Thomas Frieden will take over as the head of the Centers for Disease Control and Prevention today, according to various news outlets.
Nile Therapeutics, Inc. (Nasdaq: NLTX), a company focused on the development of novel therapeutics for heart failure patients, received notification from the U.S. Food and Drug Administration (FDA) that the agency has released the Company"s CD-NP development program from clinical hold.
Obama"s Health Cost Illusion Wall Street Journal
The antiabortion-rights movement"s presence in Wichita, Kan., faces an uncertain future as its leaders re-examine their strategy after the shooting death of Kansas abortion provider George Tiller, the New York Times reports. According to the Times, Wichita has been a center for the antiabortion-rights movement for almost two decades primarily because of the location of Tiller"s clinic, which is one of the few in the U.S. that performs abortions later in pregnancy. Most notably, thousands of protesters converged on the city in the summer of 1991, known as the "Summer of Mercy," and the city is known as a "hot spot" for groups opposed to abortion rights, the Times reports. Antiabortion-rights group Operation Rescue moved its headquarters to Wichita to focus on Tiller"s clinic, and there are five other operations in the city aimed at discouraging women from having abortions. However, many groups are concerned that interest in the antiabortion-rights movement and donations in support of the cause will drop without the presence of Tiller and his patients. Troy Newman, president of Operation Rescue, said that he does not "know what the future holds" and that it is "too early to say what comes next" for the movement. He added that Scott Roeder, the man charged with Tiller"s murder, "did more to damage the pro-life movement than you can imagine."According to the Times, the antiabortion-rights movement is facing increasing backlash related to the murder, with some abortion-rights supporters saying that abortion-rights opponents" inflammatory rhetoric helped incite the violence. Mark Gietzen, president of the Kansas Coalition for Life, said that there also is disagreement among antiabortion-rights groups over whether their leaders should have issued statements condemning the murder. Tiller"s clinic currently is closed, and no patients are being given appointments, although his family said in a recent statement that it would like to continue his work, according to the Times. David Gittrich, development director of Kansans for Life, said that although Tiller"s murder will "change things in the pro-life movement ... until abortion is illegal, unthinkable and unacceptable, there"s going to be plenty of things for pro-lifers to do" (Davey, New York Times, 6/8).Justice Department Launches Federal Probe of Murder Meanwhile, the Department of Justice on Friday began a federal investigation into Tiller"s murder and is seeking to determine whether more than one person was involved in the shooting, the Times reports. Federal officials will review evidence and look into possible violations of the Freedom of Access to Clinic Entrances Act, according to DOJ. The investigation will be conducted alongside Kansas" murder prosecution. A DOJ spokesperson would not comment on whether the investigation would affect the jurisdiction in which Roeder is eventually tried (Cullotta, New York Times, 6/6).Abortion Providers, Advocates Respond to Comments from Suspect In related news, abortion-rights providers and advocates responded to Roeder"s recent comments implying that more violence against abortion providers is planned, the AP/Google.com reports. In an interview with the Associated Press, Roeder said that there are "many other similar events planned around the country as long as abortion remains legal." Roeder refused to elaborate on his statement, and law enforcement officials said that they are not sure if his statement is legitimate. LeRoy Carhart, an abortion provider who practiced at Tiller"s clinic, noted that Tiller was not the first abortion provider to be murdered, adding, "There is more than one lunatic running loose in this country that can be influenced by the religious rhetoric." Nancy Keenan, president of NARAL Pro-Choice America, said she believes it is "imperative for anti-choice groups to tone down that rhetoric and keep the more extreme elements in their movement from copying" Roeder (Hegeman, AP/Google.com, 6/8).NPR Examines FACE Act, Antiabortion ViolenceNPR"s "Morning Edition" on Friday examined th
Antiabortion-rights legislators in Kansas plan to push for harsher restrictions on abortion when the next legislative session begins in January 2010, despite increased tensions following the murder of abortion provider George Tiller, the AP/Indianapolis Star reports.According to state House Judiciary Committee Chair Lance Kinzer (R), the debate over abortion rights should continue in the state because some laws aimed at restricting abortion access are not being enforced properly. This year, Kinzer pushed legislation (S.B. 218) to strengthen the state"s restrictions on abortions performed later in pregnancy, but the bill was vetoed by former Gov. Kathleen Sebelius (D). Gov. Mark Parkinson (D) has said his views are "very similar" to those of Sebelius on abortion rights. On Monday, he called on advocates on both sides of the issue to tone down their rhetoric. Parkinson also has said that Kansas should aim to reduce unplanned pregnancies.State Rep. Tom Sawyer (D), who supports abortion rights, said he would like to see legislators take one year off of debating the issue, adding that he thinks this is unlikely. He said, "It"d be nice to have one session where we didn"t have to debate it," adding, "People who are adamant, who keep bringing up these issues, are going to keep bringing them up. I don"t think [Tiller"s murder] is going to slow them down."However, state House Speaker Mike O"Neal (R) said tensions over abortion rights "will calm down a great deal" in the coming months. He added, "All those issues are still there. As long as the parties on both sides behave themselves and not let the rhetoric get out [of] hand, I think we can stay focused on the issues." State Sen. Tim Huelskamp (R) said that abortion-rights opponents likely will focus in the short term on the Board of Healing Arts, which licenses and regulates physicians, and the courts. A criminal case against a Planned Parenthood clinic in Johnson County, Kan., is pending (Hanna, AP/Indianapolis Star, 6/5).
"When a Supreme Court nominee such as Judge Sonia Sotomayor comes before the Senate for confirmation, she is promised a full, fair hearing," yet "every nominee"s path is booby-trapped by the history of previous confirmation battles," Washington Post columnist David Broder writes. Broder examines prior confirmation hearings, noting that the "[o]ne thing that may make it harder to forget the partisan and ideological battles of the past is that President Obama found reasons to oppose" Chief Justice John Roberts and Justice Samuel Alito while he was in the Senate.During Roberts" confirmation hearing, Obama said that although he was "sorely tempted to vote for Judge Roberts," he had issues with Roberts in cases where "precedent and rules of construction" are insufficient and where justice "can only be determined on the basis of one"s deepest values." Obama added that the rights of women and minorities are dependent on cases in which "the critical ingredient is supplied by what is in the judge"s heart." Obama said Roberts" record on women"s rights and other issues was not strong enough to quell doubts about Roberts" "deepest values."Broder continues, "Based on the Obama precedent, the White House can hardly complain if Republicans push beyond the question of Sotomayor"s qualifications and examine her values -- and her biases." He concludes, "Someday, the Senate may again be satisfied to examine only professional credentials, recognizing the uncertain dynamics of a nine-person bench," but while past precedents survive, "that is not likely" (Broder, Washington Post, 6/4).
Clinical investigators observed that Soliris® (eculizumab), a first-in-class terminal complement inhibitor developed by Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN), reduced hemolysis (red blood cell destruction) and improved symptoms in nine patients with paroxysmal nocturnal hemoglobinuria (PNH) who had received no blood transfusions prior to initiating Soliris therapy.
Women are under-represented in clinical cancer research published in high-impact journals, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
PLC Systems Inc. (OTC Bulletin Board: PLCSF), a company focused on innovative cardiac and vascular medical device-based technologies, announced that it will demonstrate its RenalGuard System(TM) at EuroPCR, the annual meeting of the European Association of Percutaneous Cardiovascular Interventions (EAPCI), May 19-22, 2009, in Barcelona, Spain. More than 11,000 clinicians and professionals are expected to attend this event.
PanGenetics B.V. announced that the Competent Authority of the Netherlands has approved the Clinical Trials Application for a first-in-man study with antibody PG110. This humanized antibody is a member of the class of Nerve Growth Factor (NGF) inhibitors which represent a promising novel approach in the treatment of chronic pain. PG110 will be evaluated in patients suffering from pain caused by osteoarthritis (OA). The clinical trial is designed as a double blind, placebo controlled study and will be conducted in a single site in Utrecht, the Netherlands, in collaboration with Kendle International.
Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) announced that data from CTI"s pivotal phase III EXTEND (PIX301) trial of pixantrone in patients with advanced, relapsed aggressive non-Hodgkin"s lymphoma (NHL) will be presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting, which will be held from May 29 to June 2, 2009 in Orlando, Florida.
AAMC (Association of American Medical Colleges) President and CEO Darrell G. Kirch, M.D., issued the following statement today on U.S. Department of Health and Human Services Secretary Kathleen Sebelius"s recent announcement that the National Health Service Corps (NHSC) would provide nearly 3,300 new loan repayments for health professions training. The $200 million in repayment funds were made possible by the American Recovery and Reinvestment Act (ARRA):
Not everyone declines in cognitive function with age. Elderly people who exercise at least once a week, have at least a high school education and a ninth grade literacy level, are not smokers and are more socially active are more likely to maintain their cognitive skills through their 70s and 80s, according to research published in the June 9, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Napping may have a significant influence on young children"s daytime functioning, according to a research abstract presented on Monday, June 8 at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
A majority of high-risk stroke patients are less likely to meet clinical treatment targets to prevent repeat stroke or heart attacks compared to those with heart disease, suggesting the need to examine new therapeutic strategies, according to a study led by St. Michael"s Hospital neurologist Dr. Gustavo Saposnik. What"s more, medical procedures or ongoing specialty care may improve patients" awareness and consequent treatment success.
Scientists at South Dakota State University are exploring the mechanisms by which a substance derived ultimately from Red Sea coral could help treat skin cancer.
Lyme disease is emerging in Canada, and is expected to increase with climate change, but effective, enhanced surveillance and clinician awareness will be key to minimizing the impact of the disease, write researchers in a review in CMAJ .
Ontario children are more likely to get diagnosed with diabetes than their American counterparts. A study out of the Institute for Clinical Evaluative Sciences (ICES) has found a 3 per cent increase per year in the rate of diabetes in Ontario children from 1994 to 2004.
Alzheimer"s disease and its precursor, mild cognitive impairment, appear to be associated with an increased risk of death among both white and African American older adults, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.
University of Florida scientists have discovered why a paralyzing brain disorder speeds along more rapidly in some patients than others - a finding that may finally give researchers an entry point toward an effective treatment for amyotrophic lateral sclerosis, often referred to as ALS or Lou Gehrig"s disease.
Micro Imaging Technology, Inc. (OTCBB: MMTC) announced that it has received AOAC Research Institute (AOAC RI) Performance Test Method™ (PTM) certification for the MIT 1000 System"s (System) identification of Listeria species (PTM Certificate Number 060901). Listeria are known to be the bacteria responsible for listeriosis, a rare but lethal food-borne infection that has a devastating case fatality rate of 25% (Salmonella, in comparison, has a less than 1% mortality rate). They are incredibly hardy and able to grow in temperatures ranging from 4°C (39°F), the temperature of a refrigerator, to 37°C (99°F), the body"s internal temperature. Furthermore, listeriosis" deadliness can be partially attributed to the infection"s ability to spread to the nervous system and cause meningitis.
Scientists at the University of Leicester are developing new ways of studying how brain cells work -thanks to jellyfish!
Promoting the health of young children, before five years of age, could save society up to $65 billion in future health care costs, according to an examination of childhood health conducted by researchers at the Johns Hopkins Bloomberg School of Public Health. The results are published in the May 15, 2009, issue of Academic Pediatrics.
Methuselah Foundation has identified Organovo, Inc. as a leader in the extraordinary science of bio-printing. The US Department of Health and Human Services predicts: "Within 20 years regenerative medicine will be the standard of care for replacing all tissue/organ systems in the body." Organovo, with the support of Methuselah Foundation, is applying its breakthrough organ printing technologies to make that prediction a reality.
Unilever and the World Heart Federation announce a joint initiative to promote awareness of Heart Age - a new, personally motivating way of expressing an individual"s risk of developing heart disease and stroke.
The Centers for Disease Control and Prevention (CDC) has downgraded its Travel Health Warning that recommended against non-essential travel to Mexico to a "Travel Health Precaution". The CDC says it has been monitoring the swine flu (H1N1) outbreak in Mexico together with Mexican authorities, and now has a more comprehensive picture of the current behavior of the outbreak.
On June 17 from 6.30pm to 8.30pm, Terrence Higgins Trust is launching a new Positive Self Management Programme for gay men living with HIV. The free workshops in Ladbroke Grove, London will run at the same time every subsequent Tuesday for seven weeks.
On Monday, House Ways and Means Committee Chairman Charles Rangel, D- N.Y., told reporters that the House bill will include a new public insurance plan, Reuters/The Boston Globe reports. "Similar to legislation being developed in the Senate, the House bill would establish an insurance exchange to help people without employer-sponsored insurance find medical coverage." The government-sponsored public insurance plan would be "one of the options available, lawmakers said." The bill would also establish a mandate that would "require individuals and businesses to obtain coverage."
Bloomberg reports that "While the House Democrats" plan would boost Medicare payments to primary-care physicians, it will also cut payments to Medicare Advantage health plans. Details of those cuts weren"t provided." Bloomberg details other features of the legislation: "An outline of the plan also says Democrats drafting the House bill will propose new restrictions on insurers, including caps on out-of-pocket health-care expenses in policies to protect consumers from bankruptcy. The legislation also would bar insurers from excluding people based on pre-existing conditions, according to the outline, a copy of which was obtained by Bloomberg News" (Litvan and Rowley, 6/9).
"Black, Latino and Asian lawmakers want President Barack Obama to focus more on racial disparities reported in medical treatment as the White House works toward overhauling the nation"s health care system," the Associated Press reports. "Members of the Congressional Black Caucus sent Obama a letter last week calling for more attention to minority health problems" and are "expected to join lawmakers from Hispanic and Asian caucuses Tuesday at a news conference on Capitol Hill." They plan to "introduce an alternative health care proposal soon that would improve services in low-income areas, eliminate language barriers and improve data collection to help detect gaps in care for various racial and ethnic groups" (Evans, 6/9).
According to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, older adults are able to retain better cognitive functioning during sleep deprivation than young adults.
Older Americans with depressive symptoms and poor mental health tend to get seven hours of sleep per night or less, according to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
In places where young women outnumber young men, research shows the hemlines rise but the marriage rates don"t because the young men feel less pressure to settle down as more women compete for their affections.
Three researchers from the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed and evaluated a new one-step bioanalytical approach that allows them to profile in detail complex cellular extracts of proteins. The method has allowed the scientists to look at how the levels of proteins change in breast cancer cells when they are treated with hormones or cancer drugs like tamoxifen.
House Republicans on Wednesday sent President Obama a letter urging "open and constructive dialogue across party lines" on health care reform and calling on him to maintain current restrictions on federal funding of abortion services, Politico reports. The letter, signed by House Minority Leader John Boehner (Ohio), House Minority Whip Eric Cantor (Va.), House Republican Conference Chair Mike Pence (Ind.) and six other Republican House members, outlines the Republicans" positions on health care reform. It says achieving those objectives "can be accomplished through health reform that maintains current law provisions regarding restrictions on federal funding of abortion services, restricts federal funds from flowing to abortion providers and does not impose mandates either on insurance carriers or medical providers to participate in activities that violate their religious and moral beliefs."The letter says that Republicans have several "areas for potential common ground on health care reform." In all, it mentions the phrase "common ground" four times in eight paragraphs, Politico reports (Allen, Politico, 5/13).
UK charity the Blood Pressure Association has responded to the American Medical Association CARDIA Sleep Study - "Association Between Sleep and Blood Pressure in Midlife", published in Archives of Internal Medicines (volume 169, no. 11)
Hormone therapy is often given to patients with advanced prostate cancer. While it is true that the treatment prevents growth of the tumour, it also changes its properties. Some of these changes may result in the tumour becoming more aggressive and more liable to form metastases. This is one of the conclusion of a thesis presented at the Sahlgrenska Academy.
Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance.
In a world-first breakthrough, University of New South Wales (UNSW) medical researchers have used stem cells cultured on a simple contact lens to restore sight to sufferers of blinding corneal disease.
Restaurants in Germany legally sell alcohol to teenagers after their sixteenth birthdays and French children drink wine with dinner at an early age, but U.S. parents who follow this relaxed European example, believing it fosters a healthier attitude toward alcohol, should be careful -- it may increase the likelihood that their children binge drink in college.
The most important factors for a successful stay in hospital short-stay units (SSUs) are the types of diagnostic tests performed and whether or not specialty consultations are needed. When hospitalists staff these units, they can ensure that only patients who need readily accessible services are admitted. These are the findings of a study published in the Journal of Hospital Medicine.
Hormonal changes early in pregnancy cause maternal postpartum anxiety and behavior changes that can lead to a delayed onset of puberty in both birth and adoptive daughters, according to a new study conducted in mice. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
The Royal Society for Public Health (RSPH) announces it will be delivering training sessions for the RSPH Level 1 Health Awareness and the RSPH Level 2 Understanding Health Improvement awards.
President Obama on Friday appointed New York City Health Commissioner Thomas Frieden as CDC director, according to Obama administration officials, the New York Times reports. According to the Times, Frieden, an infectious disease specialist, has "cut a high and sometimes contentious profile" in his seven years as health commissioner in New York City, during which time he has advocated for a smoking ban in restaurants and bars, made HIV testing part of routine medical exams and protected a program that distributes 35 million condoms a year. According to the Times, Frieden is expected to take office next month. The Times reports that he will "inherit a host of immediate and long-term problems," including questions surrounding a vaccine for the H1N1 influenza virus, also known as swine flu, health care reform and organizational issues at CDC.The Times reports that a potential advantage for Frieden is a positive relationship with likely FDA Commissioner Margaret Hamburg, who also was New York City health commissioner. Frieden would work with Hamburg to combat the H1N1 flu virus and to re-evaluate the U.S. food safety system (Harris/Hartocollis, New York Times, 5/15).
New data presented at the American Diabetes Association (ADA) 69th Annual Scientific Sessions showed that initial treatment with "Janumet"* (sitagliptin/metformin) provided significantly greater blood sugar improvements in drug-naç¯ve** patients with type 2 diabetes, compared with metformin alone.[i]
Sysmex America, Inc. announced that a study titled "Day-to-Day, Week-to-Week, and Day-of-the-Week Variations in Tests of Anemia and Iron Status in Hemodialysis Patients" has identified Sysmex"s Reticulocyte Hemoglobin Equivalent (RET-He) parameter result as key input used by physicians to assist in Anemia treatment decisions in ESRD patients on hemodialysis. David Van Wyck, M.D., Vice President of Clinical Affairs at DaVita Inc., and Emeritus Professor of Medicine and Surgery at the University of Arizona College of Medicine, in Tucson et. al followed five hematologic parameters in 30 patients undergoing hemodialysis three times a week. The patients were followed for 12 consecutive treatment days. The parameters studied were Hb, Hct, reticulocyte Hb (RET He or CHr), TSAT and ferritin levels.
VNUS(R) Medical Technologies, Inc. (Nasdaq: VNUS), a worldwide leader in medical devices for the minimally invasive treatment of venous reflux disease, announced that the Journal of Vascular & Interventional Radiology, the prestigious monthly publication of the Society of Interventional Radiology, has published a study showing the VNUS ClosureFAST(TM) system for radiofrequency (RF) thermal ablation to be "significantly superior" to endovenous laser (EVL) for treating venous reflux, the underlying cause of symptomatic varicose veins.
MonoSol Rx, the developers of PharmFilm(R) technology and a drug delivery company specializing in dissolving thin film pharmaceutical products, announced that the new drug application (NDA) for ondansetron orally dissolving film strip (ODFS) has been accepted for review by the U.S. Food and Drug Administration (FDA). Ondansetron ODFS was developed using MonoSol Rx"s proprietary PharmFilm(R) technology to deliver the anti-emetic therapy ondansetron in a thin film strip that rapidly dissolves on the tongue.
Strativa Pharmaceuticals, the proprietary products division of a wholly owned subsidiary of Par Pharmaceutical Companies, Inc. (NYSE: PRX), today announced that the U.S. Food and Drug Administration (FDA) has accepted its New Drug Application (NDA) for ondansetron orally dissolving film strip (ODFS). Strativa is seeking approval of ondansetron ODFS for the prevention of nausea and vomiting associated with highly- and moderately-emetogenic chemotherapy, radiotherapy and surgery.
A Selection of Opinions and Editorials
Researchers at UMDNJ-Robert Wood Johnson Medical School are a step closer to treating, and perhaps preventing, muscle damage caused by disease and aging. In their study, published in the June issue of Journal of Biological Chemistry, the scientists have linked the newly discovered protein MG53 to a pathway that repairs human muscle tissue along with the proteins caveolin-3 (Cav3) and dysferlin. Prior to this study, the underlying interactions that inhibited membrane repair in muscle tissue were unknown. Linking these proteins creates a mechanism that allows damaged membranes to be repaired, which may transform treatment for patients who suffer from severe complications of diseases such as muscular dystrophy, as well as cardiovascular disorders and conditions related to advancing age.
NIH and the advocacy group Autism Speaks are enrolling 1,200 pregnant women who have other children with autism spectrum disorders to participate in a large study that aims to identify early signs of the condition and its possible causes, the Wall Street Journal reports. Women who participate in the study -- known as the Early Autism Risk Longitudinal Investigation, or EARLI, study -- will be monitored throughout their pregnancies, and their infants will be monitored until age three. The Centers for Disease Control and Prevention estimates that one in 150 children in the U.S. has an autism spectrum disorder, which includes autism, Asperger"s syndrome and pervasive developmental disorders. The study will focus on women who already have one child with an autism spectrum disorder because such women have a higher chance of having another child with the condition. Craig Newschaffer, the study"s lead investigator and a department chair at Philadelphia"s Drexel University School of Public Health, said, "By studying families who are already affected by autism, we feel we have the best chance at learning how genetics and environmental factors could work together to cause autism." Autism usually is characterized by social interaction and communication impairments, as well as unusual interests or behaviors. Although there is no cure for autism, its symptoms can be improved through therapy and medication, the Journal reports.According to Newschaffer, researchers throughout the study will collect blood and urine for DNA analysis. Samples also will be collected from the umbilical cord, placenta and meconium -- the infant"s first stool -- after birth. Infants born during the study will be provided with a series of developmental assessments, and older siblings with autism also could receive assessments to confirm their diagnosis (Corbett Dooren, Wall Street Journal, 6/9).
Weatherwood Manor, a UPMC Senior Living Community, will host a health fair from 1:30 to 3:30 p.m. and a blood drive from 12 to 5 p.m., Thursday, June 11. Weatherwood Manor is located at 896 Weatherwood Lane in Greensburg.
EUROPACE, the official congress of the European Heart Rhythm Association (EHRA), is the foremost European meeting on cardiac arrhythmias and pacing. More than 4,000 participants are expected to attend this year"s event, whose main themes are atrial fibrillation and sudden cardiac death.
The Melanoma Research Alliance (MRA) announced the recipients of nearly two million dollars in grants to fund 13 individual scientists pursuing innovative melanoma research proposals. This second round of MRA grants is focused on research that addresses the gap in translational science.
The latest issue of the online journal Diabetic Hypoglycemia features an authoritative review on sulfonylureas by Professor Ian Campbell, a leading expert in oral hypoglycemia therapy.
Paul Farmer -- founder of Partners in Health and vice chair of the Department of Global Health and Social Medicine at Harvard Medical School -- said he is in discussions with the State Department about a possible Obama administration appointment to coordinate U.S. global health initiatives, the Boston Globe reports. Farmer made the announcement Monday during a meeting with HMS faculty. Farmer said that he has not decided whether he will accept the appointment if he receives a formal offer but that he is considering it, according to the Globe. The Globe reports that it was unable to confirm whether Farmer is being considered for a full-time policy position or for an advisory role or if the appointment would be a new or existing position. Several top positions at USAID -- including administrator, deputy administrator and the assistant administrator in charge of global health are vacant, the Globe reports. These positions are presidential appointments and would require Senate confirmation. In addition, Farmer could be discussing health policy positions with the State Department. Farmer did not respond for requests seeking comment. PIH and HMS also declined comment. A spokesperson at the State Department would not discuss personnel discussions that are in progress or possible new positions. Laurie Garrett, a global health policy specialist at the Council on Foreign Relations, said the administration"s announcement last week of a $63 billion, six-year initiative that aims to address HIV/AIDS, tuberculosis, malaria and other illnesses could allow new appointees the opportunity to make a significant impact in U.S. global health policy. Garrett, who has known Farmer for several years, added that she would be surprised if he is considering a government position in part because of his extensive involvement with PIH (Smith, Boston Globe, 5/15).
SCIENTISTS have found a new biomarker that can predict the outcome of breast cancers that have spread to the lymph nodes, reveal findings published in the British Journal of Cancer .
Tamoxifen is a widely used and highly successful drug in the treatment of breast cancer, though resistance to tamoxifen is still a concern in recurrent disease (affecting 25-35% of patients), since therapy resistant metastatic tumor cells are a major cause of death. In a study in this month"s Molecular and Cellular Proteomics, researchers have uncovered a protein profile that may accurately predict whether a cancer will be tamoxifen resistant.
Metoclopramide, a drug approved in the U.S. for nausea, vomiting and heartburn poses no significant risks for the fetus according to a large cohort study published in the June 11 issue of the prestigious New England Journal of Medicine, "The Safety of Metoclopramide Use in the First Trimester of Pregnancy" (N Engl J Med 2009;360:24 June 11, 2009).
Lambda Legal, a group that represents HIV-positive people, on Tuesday filed a law suit against the Fox Ridge assisted-living facility in North Little Rock, Ark., for allegedly evicting a resident because he is HIV-positive, the Arkansas Democrat-Gazette reports.The Rev. Robert Franke, a retired biology and religion professor who was diagnosed with HIV in 1987, moved into Fox Ridge, which is operated by Parkstone Living Center, in February. The day after he moved into the facility, an unidentified administrator told his daughter, Sara Franke Bowling, that her "superiors" said Franke needed to be discharged from the facility "because of his HIV." Franke disclosed his HIV status on application materials before moving into the facility. The suit alleges that Parkstone violated the Fair Housing Act, the Americans with Disabilities Act and the Arkansas Civil Rights Act and requests a permanent injunction to prevent the facility from denying apartments or services to people living with HIV/AIDS. The suit also seeks compensatory and punitive damages and attorneys" fees and costs. The case was assigned to U.S. District Judge G. Thomas Eisele. The facility declined to comment on the suit. Julie Munsell, a spokesperson for the state Department of Human Services, said Arkansas law allows for people who have been discharged for assisted-living facilities to remain in the facility pending a hearing if the discharge is appealed. Munsell said the department"s Long-Term Care Division received notice that Franke was appealing the discharge but that the appeal was later dismissed without a hearing. According to Munsell, facilities are not permitted to discharge residents based on medical diagnoses but that some facilities have said they do not have the capacity to provide care for certain conditions. Munsell also said that Fox Ridge is "claiming that they did not admit this client so there is no need for a hearing." Scott Schoettes, staff attorney for Lambda"s HIV Project, said that Franke was not seeking medical care from Fox Ridge, although the facility does provide medical services. "He didn"t require any services beyond which they were licensed to provide," Schoettes said. Franke"s eviction is "particularly blatant and egregious, but unfortunately, not all that uncommon," Schoettes said, adding, "This happens all across the country. We want to send a message that this kind of discrimination is not going to be tolerated" (Satter, Arkansas Democrat-Gazette, 5/13).
The Health and Safety Executive (HSE) is warning employers to ensure they have adequate safeguards in place to prevent access to dangerous parts of their machinery. This warning follows HSE"s prosecution of Metal Containers Ltd (formerly trading as Greif UK Ltd) after an employee"s one finger was broken in two places and another injured in the unguarded rotating part of a chained conveyor.
Mayo Clinic researchers are reporting that persons who undergo bariatric surgery may have a greater chance of experiencing broken bones, especially in their hands and feet. The study is based on a review of nearly 100 surgical cases at Mayo spanning 21 years and presented at the Endocrinology Society Annual Meeting in Washington, D.C.
Emergent BioSolutions Inc. (NYSE:EBS) announced that its flagship product, BioThrax® (Anthrax Vaccine Adsorbed), has been granted a shelf life extension from 3 to 4 years by the U.S. Food and Drug Administration (FDA). Based on this approval, Emergent has achieved a contract milestone warranting a payment of approximately $30 million for doses previously delivered to the Strategic National Stockpile (SNS) under the terms of the company"s existing BioThrax procurement contracts with the Department of Health and Human Services (HHS). This amount is expected to be recognized as revenue in the second quarter of 2009. In addition, FDA approval of 4-year expiry dating results in an immediate price increase for the future delivery of BioThrax doses under the current contract as well as under the follow-on multi-year contract, valued at $405 million, for the delivery of 14.5 million doses of BioThrax.
Biothera has initiated a Phase II clinical trial in stage IV KRAS-mutated colorectal cancer patients with its investigational drug Imprime PGG® in combination with Erbitux® (cetuximab), the company announced today.
Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone, and muscle, today announced it will provide three oral presentations on data from its ACE-031 program at the Endocrine Society"s 91st Annual Meeting to be held in Washington, DC from June 10-13, 2009. The presentations will provide results from preclinical studies highlighting the effects of its lead investigational product for treating diseases involving the loss of muscle mass and function.
New Era examines discussions at the meeting over how "an acute scarcity of financial res is threatening to set back the commendable strides achieved in the global fight against HIV/AIDS pandemic within the next three to five years." The Global Fund To Fight AIDS, Tuberculosis and Malaria"s Director for the Africa Unit Fareed Abdullah said during a news briefing at the conference, "There is no[t] enough money on the table for antiretroviral (ARV) treatments. It is a massive conundrum. The funding gap would start to hit in the period going forward."