Sexual Health
Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT), a specialty pharmaceutical company focused on the development and commercialization of proprietary products that address important therapeutic needs in the field of neuroscience, announced today the presentation of two posters at the 2009 annual meeting of the American Psychiatric Association in San Francisco, California.
According to the US Centers for Disease Control and Prevention (CDC), vaccination with seasonal flu vaccines made for the 2005 to 2009
A new study finds that nearly one in four African American women with late stage breast cancer refused chemotherapy and radiation therapy, potentially life saving therapies. Published in the July 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that more efforts are needed to ensure that all women with breast cancer receive appropriate care.
While young men with prostate cancer have a low risk of dying early, those with advanced forms of cancer do not live as long as older men with similar forms of the disease. That is the conclusion of a new study published in the July 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The paradoxical findings indicate that there may be biological differences between prostate cancers that develop in younger men and those that develop in older men, and that uncovering these differences may help tailor screening and treatment strategies for patients based on age.
PGxHealth, a division of Clinical Data, Inc. (NASDAQ: CLDA), a biotechnology company developing targeted therapeutics and genetic and pharmacogenomic tests to detect diseases and predict drug safety, tolerability and efficacy, announced at the Heart Rhythm Society meeting that it will double the number of genes in its FAMILION Long QT Syndrome (LQTS) Test. By detecting genetic mutations in individuals and their families, the FAMILION LQTS Test can help guide treatment to prevent possible sudden cardiac death. This newly enhanced LQTS Test follows the 3-gene expansion of the FAMILION Hypertrophic Cardiomyopathy (HCM) Test released earlier this year and demonstrates the Company"s leadership in genetic testing for inherited cardiac disorders.
Supporters of Planned Parenthood of Kansas and Mid-Missouri are urging Gov. Mark Parkinson (D) to veto a provision in a budget bill (H.B. 2373) that would eliminate the group"s funding, the AP/Wichita Eagle reports. The bill aims to balance Kansas" budget for the fiscal year that begins July 1. The original bill was approved by the Legislature and former Gov. Kathleen Sebelius, who resigned in April to become HHS secretary. It included $250,000 in state funding for Planned Parenthood for FY 2010. However, lawmakers later amended the budget with a new bill that includes a provision eliminating the funding after state revenue projections declined, the AP/Eagle reports.While antiabortion-rights advocates want Parkinson to retain the provision, about two dozen supporters of Planned Parenthood gathered on Tuesday to urge Parkinson to line-item veto the provision. They left petitions at the governor"s office with about 3,500 signatures, the AP/Eagle reports. Planned Parenthood attorney Pedro Irigonegarary said the loss of funding would negatively impact "a large number of innocent people." He added that the group "is about family values. They have taken those two words from us and now it"s time to take them back." According to the AP/Eagle, Planned Parenthood said the state funding is given to its Ellis and Sedgwick county clinics, which do not perform abortions. The group also noted that no state funds are used for abortion procedures performed at its clinics in Overland Park, a suburb of Kansas City.The governor"s office said that Parkinson intends to act on the bill sometime this week, although he will not announce what action he will take on any legislation in advance. Parkinson has said that he holds "very similar" views on abortion rights as Sebelius, who supports such rights. However, he has yet to act on any bills regarding abortion, the AP/Eagle reports. Mary Kay Culp, executive director of Kansans for Life, said that the group is asking members to contact legislators and the governor"s office in support of retaining the measure. The AP/Eagle reports that if Parkinson vetoes the measure, lawmakers could attempt to override it (Manning, AP/Wichita Eagle, 5/19).
Former President Clinton has joined efforts to raise money for HIV/AIDS, tuberculosis and malaria from travelers purchasing electronic airline tickets, the New York Times reports. At a press conference in Paris with United Nations special advisor Philippe Douste-Blazy, Clinton said, "If you provide a user-friendly, efficient way of giving, the contributors will use this system."The U.N. is behind the effort, which will enable travelers to voluntarily add a $2 donation for projects to fight malaria, tuberculosis and AIDS when buying an airline ticket, the Times reports. Both Clinton and Douste-Blazy are working with a newly formed group - Leading Innovative Financing for Equity, or LIFE. LIFE is comprised of eight different groups working to raising money for health aid. According to Douste-Blazy, efforts targeting small donors will begin in January 2010. He added that "the idea is that the citizens of the world are connected by the Internet and credit cards and can show their solidarity."The groups also hope to reach people renting cars, booking hotels or buying train tickets, the Times reports (Carvajal, New York Times, 5/21). Clinton said U.S. air passengers will be able to voluntarily participate in the program, adding, "There is no question that huge numbers of people will participate in this. They understand that it doesn"t cost much and that 100% will go to save lives." (AFP/Google.com, 5/20).
POZEN Inc. (NASDAQ: POZN) reported that AstraZeneca has made the decision to have POZEN file the New Drug Application (NDA) for PN 400 with the United States Food and Drug Administration (FDA). POZEN continues to target a mid-2009 NDA filing and expects to receive a milestone payment of $10 million when the NDA is formally accepted for submission by the FDA.
East African health officials on Tuesday met in Kisumu, Kenya, to examine integrating HIV/AIDS issues into transport policies in the region, Xinhua/CRI.com reports. The East African Community in a statement released ahead of the conference on Monday said that the meeting, which runs through Friday, brings together more than 100 stakeholders at the national and regional levels, including experts from national AIDS commissions, as well as representatives from transport, health, trade, immigration, gender and youth ministries. Representatives from Burundi, Kenya, Rwanda, Tanzania and Uganda are attending the conference. Other representatives include those from the Lake Victoria Basin Commission, Lake Victoria Fisheries Organization, USAID, the International Organization for Migration, the Port Management Association of Eastern and Southern Africa, East Africa Trade and Transport, and the East, Central and Southern African Health Community. Delegates from the EAC Regional Inter-Parliamentary Forum on Health, Population and Development also are attending.The meeting aims to promote improved regional coordination and quality of HIV services for at-risk populations by bringing together national and regional efforts along major land, sea, ocean and inland transport systems. It also will provide an update on studies conducted to determine HIV transmission modes in the region, as well as identity appropriate HIV/AIDS prevention, care, treatment and support initiatives for communities located on transit hubs and corridors. According to the EAC statement, the meeting will identify ways for the transport sector to work in partnership with various implementing partners and local communities to address HIV/AIDS (Xinhua/CRI.com, 5/19).
The Government of Canada has announced a new study that will increase the understanding of common health problems affecting seniors. David Sweet, Member of Parliament for Ancaster-Dundas-Flamborough-Westdale, made the announcement on behalf of the Honourable Leona Aglukkaq, Minister of Health.
Scientists have uncovered how and why limbs are targeted by thalidomide - the drug that caused serious defects in babies whose mothers had taken it to relieve their morning sickness.
Zannos Grekos, MD, a featured speaker at the at the 17th Annual World Congress on Anti-Aging Medicine and Regenerative Biotechnologies, announced one year follow-up results for a pulmonary hypertension patient treated with his own activated stem cells.
BioAlliance Pharma SA (Paris:BIO), a company dedicated to therapies and supportive care for cancer and AIDS patients, announced its scientific communications at upcoming international conferences on infectious diseases and oncology:
A new study published online in Nature Immunology ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. Researchers led by Jane A. Skok Ph.D., assistant professor in the Department of Pathology at NYU School of Medicine and a member of the NYU Cancer Institute, showed that the V(D)J recombinase, which consists of the RAG1 and RAG2 proteins, mediates this pairing and helps ensure that only one allele undergoes recombination at a time (a process known as allelic exclusion).
This is a personal account of my battle so far with prostate cancer. My name is Christian Nordqvist, 53, Editor of Medical News Today. On 26th of March, 2009, I underwent a radical prostatectomy - in other words, I had my prostate taken out. A biopsy had detected cancerous tissue in the prostate. Before that, a routine check-up had revealed higher than normal levels of PSA in my blood. After discussing various options with my urologist, we decided that radical prostatectomy was best for me. There were two compelling reasons for this - I am 53 (relatively young for this type of disease), and I have a family history of prostate cancer.
Most of the current obesity research is not proving helpful in finding solutions to the growing international epidemic, according to a Deakin University public health expert.
In comparing ultrasound with other medical imaging methods such as MRI and CT scans, a literature review of published studies in the May/June issue of Journal of Diagnostic Medical Sonography (JDMS) describes the use of ultrasound to provide an accurate diagnosis more cost effectively than the alternatives.
Boehringer Ingelheim will present new data on the company"s two lead oncology compounds, BIBW 2992 and BIBF 1120 at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO), the company announced today. Two studies in the LUX-Lung clinical development program for BIBW 2992 and a Phase II study of BIBF 1120 in ovarian cancer patients will be presented.
Aerosol delivery of antibiotics via nanoparticles may provide a means to
Genomic Health, Inc. (Nasdaq: GHDX) announced positive results from the landmark QUASAR validation study, which demonstrated that the Oncotype DX(R) colon cancer test can independently predict individual recurrence risk in stage II colon cancer patients following surgery. Importantly, the Oncotype DX colon cancer Recurrence Score(R) provided additional independent clinical value beyond standard measures. The study showed that the colon cancer Recurrence Score maintained significance (p=0.008), independent of mismatch repair (MMR), also known as MSI (Microsatellite Instability), T-stage, nodes examined, grade and lymphovascular invasion.
In a world first, Spain is to use a nanotechnology microscope for brain studies as part of the Blue Brain project. The initiative is CSIC researcher Javier de Felipe"s brainchild, and researchers at the Universidad Politécnica de Madrid"s School of Computing are developing a series of tools to analyse and interpret microscope data.
Drinking on college campuses in the United States is a pervasive problem, leading to numerous problems. One study estimated that more than 500,000 college students suffered alcohol-related injuries in 2001. This study examined the "dose-response" effect of quantities and frequencies, finding that heavy drinkers with a sensation-seeking disposition had the greatest risk of alcohol-related injuries.
Pregnant women with low levels of vitamin D may be more likely to suffer from bacterial vaginosis (BV) - a common vaginal infection that increases a woman"s risk for preterm delivery, according to a University of Pittsburgh study. Available online and published in the June issue of the Journal of Nutrition, the study may explain why African-American women, who often lack adequate vitamin D, are three times more likely than white women to develop BV.
Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to reduce the risk of colon cancer, act directly on cyclooxygenase-2 (COX2) and reduce its activity. Population studies have found an association of inherited variations in the COX2 gene with colon cancer risk, but others were unable to replicate this finding. Similarly, variations in the uridine diphosphate glucuronosyltransferase 1A6 (UGT1A6) gene, which is also known to be key in the metabolism of NSAIDs, have been shown to modify the effect of NSAIDs on developing colon polyps, a precursor of colon cancer, but these modifications of NSAID effects have not been observed in risk of colon cancer.
Scientists announced in New York the discovery of a 47 million year
The National Alliance on Mental Illness (NAMI) honored 41 doctors as "Exemplary Psychiatrists" at the American Psychiatric Association (APA) annual conference in San Francisco today.
Only slightly more than half of the 18 million Americans diagnosed with diabetes had their blood sugar, cholesterol, and blood pressure under optimum control in 2006, according to the latest News and Numbers from the Agency for Healthcare Research and Quality.
The U.S. Food and Drug Administration has approved Samsca tablets (tolvaptan) to treat hyponatremia, an abnormally low concentration of sodium in the blood.
Cytokinetics, Incorporated (NASDAQ: CYTK) announced that data relating to two Phase IIa clinical trials evaluating CK-1827452, one in stable heart failure patients and one in patients with ischemic cardiomyopathy and angina, are scheduled to be presented in two poster presentations and in the late breaking trials session at the 2009 Heart Failure Congress of the European Society of Cardiology, to be held May 30-June 2, 2009, at the Nice Acropolis Palais des Congrç¨s et Expositions in Nice, France.
A new study from Harvard School of Public Health (HSPH) researchers found that participants who drank for a week from polycarbonate bottles, the popular, hard-plastic drinking bottles and baby bottles, showed a two-thirds increase in their urine of the chemical bisphenol A (BPA). Exposure to BPA, used in the manufacture of polycarbonate and other plastics, has been shown to interfere with reproductive development in animals and has been linked with cardiovascular disease and diabetes in humans. The study is the first to show that drinking from polycarbonate bottles increased the level of urinary BPA, and thus suggests that drinking containers made with BPA release the chemical into the liquid that people drink in sufficient amounts to increase the level of BPA excreted in human urine.
Today, Baxter is announcing that its investigation of reports from Beebe Medical Center has determined that the three patient events are unrelated to product quality involving the company"s heparin premix products.
Researchers at the University of Toronto and the University Health Network"s Centre for Innovation in Complex Care (CICC) have found that a wide array of health-related activity occurs in the 3 dimensional virtual world of Second Life. Second Life is free for users with basic accounts, and reported over 16 million registered users worldwide in 2008. The web-based platform, which is often associated with pornography and "cheating" spouses, is also used to educate people about illness, train physicians, nurses and medical students with virtual simulations, enable disease-specific support and discussion groups, fundraise real-life dollars for medical research, and to conduct research.
Funding from the Biotechnology and Biological Sciences Research Council (BBSRC) could lead to the development of new and better treatments for broken bones and other orthopaedic problems associated with ageing.
UroToday.com - You pass what you eat! If you eat wisely, passage shouldn"t be painful. This may be especially true for stone formers. To be sure, high fluid intake resulting in a urine output of > 2 liters per day is key; however, what is eaten also plays a role. In this study among 56 hyperoxaluric patients on a low oxalate diet, the institution of a low salt (4-5 grams/day), low animal protein (approximately 20 grams per day vs. a norm of 50 grams per day), and normal calcium diet over a 3 month period, resulted in a statistically significant drop in 24 hour urine calcium (364 to 263 mg/d) and oxalate (50 to 35 mg/d).
Most women who are likely to have a bone fracture do not think they are at greater risk, said a leading Italian rheumatologist at a European conference today. This could help to explain why many women do not adhere to preventive treatment.
The National Association of Chain Drug Stores (NACDS) announced its ECON 09 Business Programs for the 2009 Marketplace Conference, to be held June 28-July 1 in Boston, Massachusetts. The presentations are new additions to the Marketplace program.
An advance in solving the mysterious machine-workers" disease
Health Canada is advising expectant mothers and breastfeeding women not to take the vitamin-mineral supplements Maxum Matragen or Maxum Multi-Vite by Seroyal International Inc. Maxum Multi-Vite has been approved as a vitamin-mineral supplement for only the general public but lacks the required cautionary statement on the label regarding pregnant and/or breast feeding women. The product Maxum Matragen is being promoted by the company as a prenatal supplement; however, neither product has been authorized for sale by Health Canada for use by women who are pregnant or breastfeeding.
National guidelines are needed for timely disclosure of medical errors and informing patients, write Toronto-based researchers in a review http://www.cmaj.ca/press/pg1125.pdf in CMAJ (http://www.cmaj.ca).
More than 11,000 neurologists, investigators and trainees gathered in Seattle in late April for the 2009 annual meeting of the American Academy of Neurology, one of this country"s top venues for sharing clinical research progress related to multiple sclerosis and other neurological disorders. This year, there were over 400 platform and poster presentations focusing on progress related to MS. This summary covers just a fraction of the platform talks. To read the researchers" original abstracts, sign up at no charge at the American Academy of Neurology"s Website.
Researchers with the Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center will continue their unique work thanks to a second $1 million grant from the Komen organization.
According to a new position statement from the National Athletic Trainers" Association (NATA), proper management of acute spinal injuries on the athletic playing field is crucial, given that sports participation constitutes the second most common cause of spinal cord injuries for Americans age 30 and younger. Sports medicine providers and others on the sidelines need to be familiar with the appropriate acute-management guidelines for athletes with cervical-spine injuries. Published in this month"s Journal of Athletic Training, NATA"s scientific publication, the position statement provides detailed guidelines for the immediate treatment and transport of athletes who are injured on the playing field.
As thousands of students nationwide prepare to leave high school, a UC Davis study appearing online in the June issue of the medical journal Pediatrics shows a clear link between attention problems early in school - as early as kindergarten - and lower high school test scores.
Researchers in Indiana are reporting an advance toward faster, more sensitive tests for detecting melamine, the substance that killed at least 6 children and sickened 300,000 children in China who drank milk and infant formula adulterated with the substance. The improved tests may ease global concerns about food safety, the researchers say. Their report is scheduled for the May 27 issue of ACS" Journal of Agricultural and Food Chemistry, a bi-weekly publication.
The relationship between the dental disease periodontitis and coronary heart disease (CHD) has been known for several years. Although a genetic link seemed likely, until now its existence was uncertain. Now, for the first time, scientists have discovered a genetic relationship between the two conditions, a researcher told the annual conference of the European Society of Human Genetics.
Reacting to the Government"s response to the Archer Report (http://www.archercbbp.com) into the contaminated blood and blood product disaster Chris James, Chief Executive of the Haemophilia Society said:
ReachMD, which provides medical news and information to healthcare practitioners, is raising its profile with the Continuing Medical Education, or CME, application for the Apple iPhone and iPod touch. This is the first CME application that lets users listen to all ReachMD Continuing Medical Education content, get regular updates on new Continuing Medical Education content and take Continuing Medical Education tests for credit, all from their iPhone or iPod touch.
AltheaDx, a world leader in the development of companion diagnostics and biopharma services, announced that they have successfully passed the State of California survey for CLIA (Clinical Laboratory Improvement Amendments) certification. AltheaDx is offering high-quality patient and biopharma molecular testing services from their state-of-the-art, GMP, GLP, and now CLIA compliant facility located in the Sorrento Valley, San Diego.
Are you a man or a mouse? A new paper, published in this week"s issue of
If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations - the regions in which the immune response is organised. However, a new paper - published in this week"s issue of PLoS Biology - suggests that lymph nodes are not essential in the mouse in marshalling T-cells (a main immune foot soldier) to respond to a breach of the skin barrier. This result is both surprising in itself, and suggests a novel function for the liver as an alternate site for T-cell activation.
The 22nd Congress of the European College of Neuropsychopharmacology (ECNP) will be held from 12-16 September 2009 in Istanbul, Turkey.
When a cancer patient and his or her doctor discuss the value of a treatment option, the conversation usually centers on a consideration of the treatment"s medical benefits versus its possible side effects for the patient. Increasingly, however, as the already high costs of cancer care continue to rise, a full view of the patient"s welfare must also take into account the economic impact of the treatment on the patient and his or her family.
Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea. The trial determined that patients with chronic lymphocytic leukemia (CLL) can tolerate the chemical fairly well when high doses are administered in capsule form and that lymphocyte count was reduced in one-third of participants. The findings appear today online in the Journal of Clinical Oncology.
A machine developed at North Carolina State University in Raleigh may allow researchers to expedite development of new tools and techniques for heart surgery. The dynamic heart system pumps fluid through a pig heart so that it continues to function like a live heart even after it"s been removed from the animal"s body. The machine will allow researchers to test and refine surgical technologies in a realistic surgical environment without the cost and time associated with animal or clinical trials, its developers say.
UQ Science continues to break new ground with the launch of the Hub of Organics Analysis, giving University of Queensland scientists access to a state-of-the-art testing facility that will cut the time taken to conduct research projects.
Eli Lilly and Company (NYSE: LLY) announced it will begin enrolling
Republican and Democratic lawmakers have been given "talking points" on health care reform to discuss with constituents during the Memorial Day recess as House and Senate committees work to develop comprehensive reform bills by mid-June, Politico reports (Budoff Brown, Politico, 5/26). According to The Hill, talking points distributed to Democrats in both chambers urge lawmakers to reassure constituents that congressional Democrats are working to improve and not threaten the current U.S. health care system. The Senate Democrats" talking points memo states, "We cannot delay this discussion any longer," adding, "Health care reform is no longer just a moral imperative, it is a fiscal imperative. If we want to create jobs and rebuild our economy, then we must address the crushing cost of health care this year" (Rushing/Alarkon, The Hill, 5/23). According to the memo, health care reform will "reduce costs to make health care affordable," "protect a patient"s choice of doctor and insurance plan" and "assure quality, affordable health care for all Americans." The memo also encourages lawmakers to hold "health care reform action forums" during the recess with constituents. House Majority Leader Steny Hoyer (D-Md.) on Friday said that Democrats "have held more than 170 health care events in their districts already, with another 100-plus events planned for the Memorial Day district work period" (Friedman/House, CongressDaily, 5/22). In a memo by Democratic strategist Paul Begala that was distributed to lawmakers along with other recess materials, Begala urges Democrats to refer to Republicans as defenders of the flaws in the current health care system, including health insurers interfering with medical decisions and helping increase health care costs. He wrote, "There is one fact that animates the Republicans" strategy. It should animate yours, as well. That fact is this: The overwhelming majority of Americans support health care reform," adding, "If health care reform were unpopular, Republicans would not resort to misleading rhetoric to mask their opposition" (Politico, 5/26).Meanwhile, the Senate Republican Conference"s "Getaway Card" for the Memorial Day recess provides lawmakers with talking points about how health care overhaul should allow for all U.S. residents to have access to affordable health coverage provided by patient-selected physicians, avoid long wait times and be "patient-centered, not Washington-centered." The House Republican leaders are encouraging members to focus on Democrats" push for a "complete government takeover of health care," while characterizing Republican efforts as the right health care reform "that puts patients first" (CongressDaily, 5/22). The kit includes four pages of tips similar to recommendations made by Republican consultant Frank Luntz (Politico, 5/26). The New York Times Magazine on Sunday included an interview with Luntz that included his views on health care reform (Solomon, New York Times Magazine, 5/24). Advocacy Groups
Children"s behavior is determined, in part, by their genes and by the settings in which they develop. A new longitudinal study describes how a family-based prevention program helped rural African American teens avoid engaging in risky behaviors, even if some of them may have had a genetic risk to do so.
A study published in the June issue of Anesthesiology has shown that a drug metabolite of the opioid morphine may be a key factor in the paradoxical increased sensitivity to pain caused by chronic morphine use. For the first time, this metabolite (called morphine-6 glucuronide, or M6G) was shown to act independently of the pain receptors typically targeted during morphine administration.
Responding to Health Secretary Alan Johnson"s announcement of a review on the impact of the European Working Time Directive on doctors" training, Dr Andy Thornley, Chair of the BMA"s Junior Doctors Committee, said:
CHICAGO, May 26, 2009 - New data show that nab-paclitaxel (AbraxaneR for Injectable Suspension) prolongs investigator-assessed, median progression-free survival (PFS) by almost seven months versus the highest standard dose of docetaxel in women with metastatic breast cancer.
A group of cancer patients, genetic researchers and professional pathologist organizations has filed a lawsuit against Myriad Genetics and the U.S. Patent Office over the patent of two genes associated with an increased risk of breast and ovarian cancers, the New York Times reports. According to the Times, the government more than 10 years ago granted Myriad the patent on the BRCA1 and BRCA2 genes, as well as the company"s genetic test that measures a patient"s risk for the cancers.The lawsuit was filed by the American Civil Liberties Union and is believed to be the first of its kind, the Times reports. The lawsuit challenges the decision to grant patents on genes to Myriad and companies like it. The plaintiffs say that patents on genes restrict medical and research efforts, while companies like Myriad have said that the patent system supports innovation by giving them a temporary monopoly after they make a discovery, thereby rewarding prior investment in research and development.Wendy Chung, the director of clinical genetics at Columbia University and a plaintiff in the case, said, "With a sole provider, there"s mediocrity." The plaintiffs say that BRCA testing would improve with market competition. Furthermore, some plaintiffs argue that certain natural materials cannot be patented. Jan Nowak, president of the Association for Molecular Pathology and a plaintiff in the case, said, "You can"t patent my DNA, any more than you can patent my right arm, or patent my blood."To date, two government panels, including the National Research Council, found no evidence that gene patents result in significant impediments to research or medical care (Schwartz, New York Times, 5/13).
Roche Diagnostics announced the launch of a new tuberculosis test for South Africa. Worldwide, South Africa is one of the countries with the highest prevalence of tuberculosis. The new kit detects different species of Mycobacterium from human sputum samples using the LightCycler® 2.0 Instrument.
A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation. Using data from the Health, Eating, Activity and Lifestyle (HEAL) study sponsored by the National Cancer Institute, part of the National Institutes of Health, the researchers found that breast cancer patients with elevated levels of C-reactive protein (CRP) and serum amyloid A (SAA) were approximately two to three times more likely to die sooner or have their cancer return than those patients who had lower levels of these proteins, regardless of the patient"s age, tumor stage, race, body mass index, or history of previous cardiovascular issues. The results of this study were published online, May 26, 2009, in the Journal of Clinical Oncology.
Research from the Northwestern University Feinberg School of Medicine has found that a less toxic, solvent-free chemotherapy drug more effectively prevents the progression of metastatic breast cancer and has fewer side effects than a commonly used solvent-based drug.
The atherosclerosis vaccine development program by AFFiRiS AG is receiving financial support from the EU"s EUROTRANS-BIO call. The respective project is being carried out in cooperation with German company EMC microcollections GmbH. The aim of atherosclerosis vaccination is to increase the amount of "good" high density lipoprotein cholesterol (HDLc) in the blood and thus reduce the occurrence of harmful fatty deposits in the arteries. Product candidates were delivered by AFFiRiS" AFFITOME(R) platform technology. The target is a protein known as CETP (cholesteryl ester transfer protein). Following vaccines for Alzheimer"s disease and Parkinson"s disease, the atherosclerosis vaccine is the third such project announced by AFFiRiS AG.
Fate Therapeutics, Inc. announced that the first patient has been treated in a Phase 1b clinical trial of FT1050, a small molecule Stem Cell Modulator (SCM) designed to increase hematopoietic stem cell (HSC) number and function through its activation of key pathways that guide cell fate. The study, which is being conducted at the Dana-Farber Cancer Institute in Boston, Massachusetts, will determine the safety and tolerability of introducing FT1050 during the standard course of dual umbilical cord blood transplant in adult patients with hematologic malignancies, such as leukemia and lymphoma, who have undergone nonmyeloablative conditioning therapy. Fate Therapeutics is developing FT1050 to improve the overall efficiency of HSC treatment by enhancing HSC proliferation and homing to the bone marrow.
Researchers have discovered a novel molecular path that predisposes patients to develop primary biliary cirrhosis, a disease that mainly affects women and slowly destroys their livers. Primary biliary cirrhosis has no known cause.
A new study found that compared with two decades ago, fewer Americans are following a healthy lifestyle. This is despite the mounting evidence
Merrill Egorin, M.D., professor of medicine and pharmacology at the University of Pittsburgh Cancer Institute (UPCI), has received the 2009 American Society of Clinical Oncology (ASCO) Translational Research Professorship for his work in improving cancer treatments and supporting the next generation of researchers.
The Indiana Alzheimer Disease Center will host a screening of HBO"s "The Alzheimer Project" from 6:30 to 8:30 p.m. Thursday, May 28, in the lower level auditorium of the Riley Outpatient Center, 601 West Drive, on the Indiana University-Purdue University Indianapolis campus.
United Auto Workers leaders on Tuesday agreed to accept up to 20% of General Motors stock, as well as concessions on labor rules and retiree health care obligations, as the automaker faces a June 1 deadline to restructure or seek bankruptcy protection, the Detroit News reports (Aguilar/Shepardson, Detroit News, 5/27). Under the deal, the voluntary employees" beneficiary association would receive 17.5% of common GM stock, $6.5 billion of preferred shares, a $2.5 billion note and warrants equal to 2.5% of GM"s stock (Reuters/USA Today, 5/27). In addition, the VEBA would receive $585 million annually in interest income on its preferred stock (Detroit News, 5/27). Another concession included in the tentative deal is the elimination of dental, vision and some prescription drug coverage for hourly retirees (Shepardson/Aguilar, Detroit News, 5/26). UAW also would hold a seat on the GM board of directors (Cho et al., Washington Post, 5/27).Because of a proposed deal announced earlier this month, the Treasury Department and UAW, together, are to own 89% of GM"s stock, meaning that if the UAW-GM deal is approved, the Treasury would own about a 70% share of GM"s stock (Detroit News, 5/26). Current bondholders would hold about a 10% stake in the company (Washington Post, 5/27). The remaining 1% would be held by existing shareholders (Detroit News, 5/26).The total 20% is about half of what was anticipated (Higgins, Detroit Free Press, 5/26). The "significant concessions" made by UAW, which was eligible to receive up to 39% of GM"s equity through the VEBA, "could mean that [GM] is attempting to appease unsecured bondholders, who charged that the UAW was getting a better deal," according to the News (Detroit News, 5/27). UAW said the revised agreement with GM was necessary for the automaker to survive, but the deal will leave hundreds of thousands of GM retirees paying higher out-of-pocket medical expenses, the Wall Street Journal reports (Stoll et al., Wall Street Journal, 5/27).UAW members are scheduled to vote on the agreement on Wednesday and Thursday (Detroit News, 5/26). However, "[e]ven with UAW approval, GM is still likely to file for bankruptcy, since bondholders are unlikely to swallow deep concessions," according to the News (Detroit News, 5/27).
Nearly 30 years after the emergence of HIV/AIDS, the global health community must develop new strategies to curb the spread of the disease in sub-Saharan Africa, some experts said Tuesday ahead of the Global Citizens Summit for Social Mobilization to End AIDS in Nairobi, Kenya, AFP/Google.com reports. The advocates also stressed the need for innovative approaches to health financing as international donors shift their attention toward other issues and as the ongoing economic downturn threatens fundraising prospects. The conference, which opens Wednesday, includes participants from 32 countries, primarily in Africa.According to Wasai Jacob Nanjakululu of Oxfam, about 90% of HIV-positive people are unaware of their status and 70% of people in need of treatment are not accessing medical care. Leonard Okello, an HIV/AIDS specialist with ActionAid International, added that the global health community is "far from winning the struggle against" HIV/AIDS. Okello said the conference will examine the shortcomings of earlier HIV/AIDS policies and explore new methods to address the disease. "There are a lot of res in HIV/AIDS programs but not much of that reaches the community," Okello said, asking, "What is it that we should radically change?" (AFP/Google.com, 5/26). According to IRIN/PlusNews, conference participants also plan to discuss "people-centered" approaches to combating HIV/AIDS at the Nairobi meeting. ActionAid Report Calls For Improvements in Basic Health Care To Address HIV/AIDS
Researchers at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, are strongly advocating a national discussion about the need to vaccinate both young men and women against HPV 16 to prevent head & neck cancers. The call comes amid growing evidence that certain cancers of the head and neck are strongly linked to HPV 16, a specific strain of the human papillomavirus (HPV) that is one of the most common sexually transmitted diseases in the United States. It is estimated that approximately 70% of Americans, both men and women, will be infected with HPV at some point in their lives.
Patients, staff and carers who support the work of the county"s leading provider of NHS services to adults with mental ill health, invited the public to join in their first "birthday" celebrations last week.
Sedentary behavior is becoming an important component of the exercise and health equation. There is new evidence that prolonged, unbroken sitting time is related to people"s risk of obesity and type 2 diabetes, according to a lecture presented today at the 56th Annual Meeting of the American College of Sports Medicine (ACSM) in Seattle. Examples of sedentary behaviors include watching television, playing video games, using the computer, reading, and doing homework.
Surfing under the influence of drugs or alcohol are two of the prime dangers facing surfing enthusiasts, according to information presented today at the 56th Annual Meeting of the American College of Sports Medicine in Seattle. Other factors include wave height, board length and interactions among surfers.
The Foundation for Digestive Health and Nutrition has announced the 2009 American Gastroenterological Association (AGA) Foundation Research Scholars. The grants have been awarded to five outstanding young gastroenterologists who promise to make significant strides in the field of gastrointestinal research.
Z-Cube Srl, the corporate venture arm of Zambon Company SpA, and Yissum Research Development Company Ltd., the technology transfer company of the Hebrew University of Jerusalem, announced today that they have entered into a license agreement for Z-Cube to develop and commercialize an innovative nanotechnology drug delivery system for the treatment of pain. The technology was invented by Professor Elka Touitou from the Department of Pharmaceutics, Faculty of Medicine, at the Hebrew University of Jerusalem.
The Lung Association congratulates Health Minister Leona Aglukkaq and the Government of Canada on its announcement of imminent changes to the federal Tobacco Act that include:
Senate Democrats on Wednesday worked with senior White House adviser David Axelrod to craft a health care message focused on affordability and choice, the AP/Contra Costa Times reports (Werner, AP/Contra Costa Times, 5/13). The meeting followed the release of a memo last week by Republican strategist Frank Luntz outlining how to criticize Democratic plans for health reform (Budoff Brown/McGrane, Politico, 5/13). Senate Majority Whip Richard Durbin (D-Ill.) said Luntz"s memo was "an interesting catalyst for us" (AP/Contra Costa Times, 5/13).Axelrod presented Democrats with polling data about what U.S. residents are seeking from a health care overhaul and discussed better word choices, such as "shared responsibility" rather than "mandates" for coverage requirements. According to CongressDaily, the meeting centered Democrats on a coordinated message that the U.S. health care system must be affordable and accessible and should be patient-focused (Edney/Condon, CongressDaily, 5/13). Sen. Evan Bayh (D-Ind.) said that many Democrats felt "unease that we did not have a strategy" to answer the attacks coming from Republicans (Pear, New York Times, 5/14). Senate Finance Committee Chair Max Baucus (D-Mont.) said, "Everybody in the room had been a little nervous that, "Gee, Democrats don"t have their act together"" (CongressDaily, 5/13). However, Bayh said that "Axelrod came to reassure us that they do have a strategy" (New York Times, 5/14). Durbin said, "This is an effort to coordinate our message so we present a health care reform effort the American people trust" (Armstrong, CQ Today, 5/13). According to Durbin, Axelrod emphasized that Democrats should continue with the campaign theme that the goal of an overhaul is to "fix what"s broken in the system and preserve what"s good" (Young, The Hill, 5/13).Sen. Charles Schumer (D-N.Y.) said, "We believe the public shares our views. But we don"t want to be overwhelmed by either res, messaging or boots on the ground." He added, "We won"t make the mistake of 1993-94." According to the New York Times, a plan developed by the administration of former President Clinton "collapsed" in the face of Republican criticism (New York Times, 5/14).
Scientists at the Medical Research Council Laboratory of Molecular Biology uncover how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired. Women who inherit a faulty version of the BRCA1 gene are at a higher risk of developing breast or ovarian cancer.
Elderly people who live below the poverty line and perceive their neighborhoods to be dangerous are more likely to have a mobility disability. Researchers writing in the open access journal BMC Public Health suggest that even perceiving one"s neighborhood as unsafe can "get into the body" and, ultimately, prove hazardous for elder health.